Metabolite profiling of obese individuals before and after a one year weight loss program

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Nina GeidenstamMartin Ridderstråle

Abstract

We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits. Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in individuals with ⩾10% weight loss. Lower baseline levels of xylitol was predictive of a greater decrease in BMI (β=0.06, P<0.01) and ⩾10% weight loss (odds ratio (OR)=0.2, confidence interval (CI)=0.07-0.7, P=0.01). Decreases in levels of isoleucine, leucine, valine and tyrosine were associated with decrease in BMI (β>0.1, P<0.05) and ⩾10% weight loss (isoleucine: OR=0.08, CI=0.01-0.3, leucine: OR=0.1, CI=0.01-0.6, valine: OR=0.1, CI=0.02-0.5, tyrosine: OR=0.1, CI=0.03-0.6, P<0.02). Diet-induced weight loss lead...Continue Reading

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Citations

Jul 15, 2017·Nutrients·Takashi UebansoAkira Takahashi
Oct 15, 2019·Klinicheskaia laboratornaia diagnostika·A A ZhlobaYu S Polushin
Dec 21, 2018·Journal of the American Heart Association·Xia JiangChristopher Kabrhel
Jun 15, 2019·Metabolomics : Official Journal of the Metabolomic Society·Oscar Daniel Rangel-HuertaAngel Gil
Aug 9, 2019·Nutrients·Krista SalliArthur C Ouwehand
May 1, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Giovanni De PergolaVincenzo Triggiani

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