Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging

Journal of Magnetic Resonance Imaging : JMRI
Lidia M Nagae-PoetscherPeter B Barker

Abstract

Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.

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Citations

Jan 30, 2014·American Journal of Veterinary Research·Kaori OnoToshihiro Watari
Sep 26, 2015·AJNR. American Journal of Neuroradiology·I E EvangelouC Limperopoulos
Apr 22, 2009·Pediatric Neurology·Erika BrighinaMario Rango
Oct 28, 2019·AJNR. American Journal of Neuroradiology·A BerringtonR E Strowd
Nov 30, 2016·Translational Psychiatry·L M RowlandP B Barker
Nov 25, 2017·International Journal of Legal Medicine·Jakob HeimerNiklaus Zoelch

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