Metabolites Linking the Gut Microbiome with Risk for Type 2 Diabetes.

Current Nutrition Reports
Tiantian Zhu, Mark O Goodarzi

Abstract

An increasing body of evidence suggests that the gut microbiome influences the pathogenesis of insulin resistance and type 2 diabetes (T2D). In this review, we will discuss the latest findings regarding the mechanisms linking the gut microbiome and microbial metabolites with T2D and therapeutic approaches based on the gut microbiota for the prevention and treatment of T2D. Alterations in the gut microbial composition are associated with the risk of T2D. The gut microbiota can metabolize dietary- and host-derived factors to produce numerous microbial metabolites, which are involved in metabolic processes modulating nutrition and energy harvest, gut barrier function, systemic inflammation, and glucose metabolism. Microbial metabolites are important mediators of microbial-host crosstalk impacting host glucose metabolism. Furthermore, microbiome-based interventions may have beneficial effects on glycemic control. Future research is required to develop personalized T2D therapy based on microbial composition and/or metabolites.

References

Dec 22, 1999·Archives of Internal Medicine·A F Hofmann
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M D SäemannG J Zlabinger
Jan 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yumei XiongMasashi Yanagisawa
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·E B Melian, G L Plosker
Mar 26, 2005·Science·Fredrik BäckhedJeffrey I Gordon
Sep 9, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Kees MeijerMarion G Priebe
Oct 7, 2011·Diabetologia·J AmarUNKNOWN D.E.S.I.R. Study Group
Jun 8, 2012·Science·Jeremy K NicholsonSven Pettersson
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Dec 14, 2012·The ISME Journal·Pieter Van den AbbeeleTom Van de Wiele
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
May 31, 2013·Nature·Fredrik H KarlssonFredrik Bäckhed
Jul 6, 2013·Science·Jeremiah J FaithJeffrey I Gordon
Aug 30, 2013·Nature·Emmanuelle Le ChatelierOluf Pedersen
Dec 10, 2013·Journal of Hepatology·Anne VriezeMax Nieuwdorp
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Apr 12, 2014·Journal of Bioscience and Bioengineering·Xiang GaoYuming Wang
May 9, 2014·Frontiers in Microbiology·Isabel Moreno-IndiasMaría Isabel Queipo-Ortuño
Jun 15, 2014·Pharmaceutical Research·Payal AgarwalJun Shao
Sep 2, 2014·Cell Metabolism·Muhammad Tanweer KhanFredrik Bäckhed
Sep 13, 2014·Mediators of Inflammation·Alessandra PudduGiorgio Luciano Viviani

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Citations

Jul 21, 2020·Diabetes, Obesity & Metabolism·Elizabeth T JensenMark O Goodarzi
Nov 10, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Magdalena KoszewiczGjumrakch Aliev
Jul 28, 2021·Annual Review of Microbiology·Almut HeinkenInes Thiele

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