Metabolites of 3-hydrazino-6-[bis-(2-hydroxyethyl)amino]pyridazine dihydrochloride in rat urine

European Journal of Drug Metabolism and Pharmacokinetics
E BerettaE Martinelli

Abstract

In 24 hr urine of rats orally given 150 mg/kg of 3-hydrazino-6-[bis-(2-hydroxyethyl)amino]pyridazine dihydrochloride (DL 150), no unchanged compound was detected. Three metabolites, less polar than DL 150, were isolated, their structures assigned by UV, MS, IR and 1H NMR spectroscopies, and confirmed by synthesis. They are: 3-[bis-(2-hydroxyethyl)amino]-6-isopropoxypyridazine (1); 3-[bis-(2-hydroxyethyl)amino]pyridazine (2); 3-methyl-6-[bis-(2-hydroxyethyl)amino]-s-triazolo[4,3-b]pyridazine (3). The metabolism of DL 150 in the rat follows some of the metabolic pathways reported for hydralazine.

References

Nov 3, 1976·Journal of Chromatography·K D HaegeleJ L McNay
Nov 1, 1973·Clinical Pharmacology and Therapeutics·M M ReidenbergC T Bello

Citations

Jan 1, 1979·European Journal of Drug Metabolism and Pharmacokinetics·A AssandriV Pagani
Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·L SimonottiG Pifferi

Related Concepts

Metazoa
Antihypertensive Agents
Metabolic Biotransformation
Thin Layer Chromatography
Drug Stability
Ethanolamines
Hydrogen-Ion Concentration
Pyridazines
Rats, Laboratory

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