Metabolites of type I, II, III, and IV collagen may serve as markers of disease activity in axial spondyloarthritis

Scientific Reports
Markéta HušákováAnne S Siebuhr

Abstract

Local inflammation in axial spondyloarthritis (axSpA) leads to the release of collagen metabolites from the disease-affected tissue. We investigated whether collagen metabolites were associated with disease activity and could distinguish non-radiographic(nr)-axSpA from ankylosing spondylitis (AS). A total of 193 axSpA patients (nr-axSpA, n = 121 and AS, n = 72) and asymptomatic controls (n = 100) were included. Serum levels of metalloproteinase (MMP)-degraded collagen type I (C1M), type II (C2M), type III (C3M) and type IV (C4M2) were quantified by enzyme-linked immunosorbent assay (ELISA). All metabolites were higher in axSpA than in controls (all p < 0.001). Serum levels of C1M, C3M, and C4M2 were increased in AS compared to nr-axSpA (43.4 ng/mL vs. 34.6; p < 0.001, 15.4 vs. 12.8; p = 0.001, and 27.8 vs. 22.4; p < 0.001). The best metabolite to differentiate between axSpA and controls was C3M (AUC 0.95; specificity 92.0, sensitivity 83.4). C1M correlated with ASDAS-CRP in nr-axSpA (ρ = 0.37; p < 0.001) and AS (ρ = 0.57; p < 0.001). C1M, C3M, and C4M2 were associated with ASDAS-CRP in AS and nr-axSpA after adjustment for age, gender, and disease duration. Serum levels of collagen metabolites were significantly higher in AS and...Continue Reading

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Citations

Jul 9, 2020·Therapeutic Advances in Musculoskeletal Disease·Mariagrazia LorenzinRoberta Ramonda
Nov 9, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Marcus Fager FerrariEva Leinoe
Jan 25, 2021·Autoimmunity Reviews·Solveig Skovlund GroenSigne Holm Nielsen

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Methods Mentioned

BETA
ESR
X-ray
blood draw
enzyme linked immunosorbent assays

Software Mentioned

GraphPad Prism
MedCalc

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