PMID: 9182507Jan 1, 1997Paper

Metabolites produced by Streptomyces kanamyceticus mutants with impaired biosynthesis of kanamycin

Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
L M GoletsV A Fedorenko

Abstract

Metabolites produced by Streptomyces kanamyceticus mutants with impaired kanamycin biosynthesis (kan mutants) were investigated by thin layer chromatography. With spectrophotometric scanning of the chromatograms the quantitative content of kanamycin A and 2-desoxystreptamine (2-DOS) in the culture fluid was determined. Five groups of the S.kanamyceticus mutants with impaired kanamycin biosynthesis at various stages were identified: kanA produced no D-glucosamine, kanB and kanC produced no 2-DOS, kanD was not able to transfer 2-DOS to the metabolites with the antibiotic activity, kanG synthesized no kanosamine.

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
L M GoletsV A Fedorenko
Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
V A FedorenkoG Kriugel'
© 2021 Meta ULC. All rights reserved