Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins

Developmental Cell
Gianluca FigliaAurelio A Teleman

Abstract

Metabolites affect cell growth in two different ways. First, they serve as building blocks for biomass accumulation. Second, metabolites regulate the activity of growth-relevant signaling pathways. They do so in part by covalently attaching to proteins, thereby generating post-translational modifications (PTMs) that affect protein function, the focus of this Perspective. Recent advances in mass spectrometry have revealed a wide variety of such metabolites, including lipids, amino acids, Coenzyme-A, acetate, malonate, and lactate to name a few. An active area of research is to understand which modifications affect protein function and how they do so. In many cases, the cellular levels of these metabolites affect the stoichiometry of the corresponding PTMs, providing a direct link between cell metabolism and the control of cell signaling, transcription, and cell growth.

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Citations

Feb 15, 2021·Experimental Cell Research·Yusuke SekineShiori Sekine
Mar 26, 2021·Frontiers in Physiology·Ava LiaghatiMary-Ellen Harper
Jul 16, 2021·Cell Death & Disease·Gaoyue JiangHuihui Li
Jul 30, 2021·Nature Communications·Hana NůskováAurelio A Teleman
Aug 3, 2021·Journal of Cellular and Molecular Medicine·Bo JiangXinying Li
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Troy A KervinMichael Overduin
Aug 21, 2021·Annals of the New York Academy of Sciences·Jennifer CableHeather Christofk

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