Metabolomic analysis in ophthalmology.

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Neshe Nazifova-TasinovaChristina Grupcheva

Abstract

Modern science takes into account phenotype complexity and establishes approaches to track changes on every possible level. Many "omics" studies have been developed over the last decade. Metabolomic analysis enables dynamic measurement of the metabolic response of a living system to a variety of stimuli or genetic modifications. Important targets of metabolomics is biomarker development and translation to the clinic for personalized diagnosis and a greater understanding of disease pathogenesis. The current review highlights the major aspects of metabolomic analysis and its applications for the identification of relevant predictive, diagnostic and prognostic biomarkers for some ocular diseases including dry eye, keratoconus, retinal diseases, macular degeneration, and glaucoma. To date, possible biomarker candidates for dry eye disease are lipid metabolites and androgens, for keratoconus cytokeratins, urea, citrate cycle, and oxidative stress metabolites. Palmitoylcarnitine, sphingolipids, vitamin D related metabolites, and steroid precursors may be used for distinguishing glaucoma patients from healthy controls. Dysregulation of amino acid and carnitine metabolism is critical in the development and progression of diabetic retin...Continue Reading

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Citations

Jan 5, 2021·Journal of Toxicology and Environmental Health. Part a·Jung Dae LeeKyu-Bong Kim
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Li Ning, He Huixin
Aug 28, 2021·Biology·Andrés Fernández-Vega CuetoHéctor González-Iglesias

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