Metabolomic analysis of 92 pulmonary embolism patients from a nested case-control study identifies metabolites associated with adverse clinical outcomes

Journal of Thrombosis and Haemostasis : JTH
O A ZeleznikC Kabrhel

Abstract

Essentials Risk-stratification often fails to predict clinical deterioration in pulmonary embolism (PE). First-ever high-throughput metabolomics analysis of risk-stratified PE patients. Changes in circulating metabolites reflect a compromised energy metabolism in PE. Metabolites play a key role in the pathophysiology and risk stratification of PE. Background Patients with acute pulmonary embolism (PE) exhibit wide variation in clinical presentation and outcomes. Our understanding of the pathophysiologic mechanisms differentiating low-risk and high-risk PE is limited, so current risk-stratification efforts often fail to predict clinical deterioration and are insufficient to guide management. Objectives To improve our understanding of the physiology differentiating low-risk from high-risk PE, we conducted the first-ever high-throughput metabolomics analysis (843 named metabolites) comparing PE patients across risk strata within a nested case-control study. Patients/methods We enrolled 92 patients diagnosed with acute PE and collected plasma within 24 h of PE diagnosis. We used linear regression and pathway analysis to identify metabolites and pathways associated with PE risk-strata. Results When we compared 46 low-risk with 46 in...Continue Reading

References

Jul 11, 2001·Bioorganicheskaia khimiia·V V BezuglovG A Buznikov
Jul 20, 2005·BMC Bioinformatics·Mikko Katajamaa, Matej Oresic
Aug 23, 2005·Proceedings of the American Thoracic Society·Victor F Tapson
Jan 25, 2006·Circulation·Nils KucherSamuel Z Goldhaber
Jan 6, 2007·Journal of Proteome Research·Sheng-qing LiShao-jun Liu
Jun 28, 2007·Proteomics·Sheng-qing LiShao-jun Liu
Jul 2, 2009·Journal of Thrombosis and Haemostasis : JTH·J A KlineM M Hogg
Oct 22, 2011·Thrombosis Research·John A WattsJeffrey A Kline
May 17, 2014·Journal of Clinical Epidemiology·Mark E GlickmanMark R Schultz
May 23, 2014·Thorax·Christopher KabrhelYuchiao Chang
Oct 16, 2016·The American Journal of Cardiology·Praveen HariharanChristopher Kabrhel
Jan 13, 2017·The European Respiratory Journal·Cecilia Becattini, Giancarlo Agnelli
Feb 6, 2017·The American Journal of Cardiology·C Charles JainIdo Weinberg

❮ Previous
Next ❯

Citations

May 28, 2020·Journal of Clinical Medicine·Hannah StevensJames McFadyen
Aug 24, 2019·International Journal of Molecular Sciences·Jin HuangFang Huang
Dec 21, 2018·Journal of the American Heart Association·Xia JiangChristopher Kabrhel
Mar 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jin HuangRaphael N Alolga
Oct 17, 2019·Journal of Proteome Research·Sarah OnidaAlun H Davies
Aug 27, 2021·Metabolites·Beata FranczykJacek Rysz
Nov 12, 2021·Journal of Proteome Research·Jason M KinchenKirk L Pappan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.