Metabolomic analysis of serum from rats following long-term intake of Chinese sausage

Food & Nutrition Research
Minxian RongHong Deng

Abstract

Owing to the contamination of chemical pollutants, especially nitrosamines and their precursors, in Chinese sausage, long-term intake of Chinese sausage may have potential health effects. This study investigated the effects of long-term intake of Chinese sausage with different contaminations of N-nitrosodimethylamine (NDMA) on rat liver and the potential biomarkers in the serum. Serum metabolomic analysis was performed by gas chromatography-mass spectrometry at weeks 7, 17, 25, and 33; simultaneously, liver histopathological examination was conducted and its relationship with the serum metabolomics was also investigated. In the study, long-term intake of Chinese sausage with different NDMA contents induced significant changes in serum metabolites and liver histopathology in rats. Metabonomic analysis showed that seven metabolites - β-alanine, 3-aminoisobutyric acid, aminooxyacetic acid, D-alanyl-D-alanine, pelargonic acid, palmitic acid (PA), and linoleic acid (LA) - in three sausage diet groups were significantly decreased at four time points, where three other metabolites were notably increased, which included putrescine, ethanolamine phosphate, and taurine. Among the various treatments, the NDMA (sausage-free) group demonstr...Continue Reading

References

Jul 27, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E J MitacekL S Caplan
Oct 24, 2013·American Journal of Epidemiology·Susanna C Larsson, Nicola Orsini
Dec 23, 2014·Food Chemistry·S S HerrmannL Duedahl-Olesen

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Citations

Jan 9, 2022·Environmental Science and Pollution Research International·Hu ZhangLihong Yin

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Methods Mentioned

BETA
PCA

Software Mentioned

Chroma Time - of - Flight ( TOF )
SPSS
DA
OPLS
SIMCA

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