Metabolomic and glycomic findings in posttraumatic stress disorder

Progress in Neuro-psychopharmacology & Biological Psychiatry
Marcela KonjevodNela Pivac

Abstract

Posttraumatic stress disorder (PTSD) is a stressor-related disorder that develops in a subset of individuals exposed to a traumatic experience. Factors associated with vulnerability to PTSD are still not fully understood. PTSD is frequently comorbid with various psychiatric and somatic disorders, moderate response to treatment and remission rates. The term "theranostics" combines diagnosis, prognosis, and therapy and offers targeted therapy based on specific analyses. Theranostics, combined with novel techniques and approaches called "omics", which integrate genomics, transcriptomic, proteomics and metabolomics, might improve knowledge about biological underpinning of PTSD, and offer novel therapeutic strategies. The focus of this review is on metabolomic and glycomic data in PTSD. Metabolomics evaluates changes in the metabolome of an organism by exploring the set of small molecules (metabolites), while glycomics studies the glycome, a complete repertoire of glycan structures with their functional roles in biological systems. Both metabolome and glycome reflect the physiological and pathological conditions in individuals. Only a few studies evaluated metabolic and glycomic changes in patients with PTSD. The metabolomics studie...Continue Reading

Citations

Mar 19, 2019·PloS One·Synthia H MellonOwen M Wolkowitz
Dec 11, 2019·Biomolecules·Lucija TudorNela Pivac
Jun 6, 2020·Frontiers in Psychiatry·Maria Salud García-GutiérrezJorge Manzanares
Jul 16, 2020·Stress : the International Journal on the Biology of Stress·Csilla Lea FazekasDóra Zelena
Apr 30, 2020·Metabolites·Joseph S MillerKevin V Hackshaw
Jun 14, 2019·Journal of Psychiatric Research·Divya MehtaUNKNOWN PTSD Initiative
Jun 3, 2021·International Journal of Molecular Sciences·Beatrix PatonNúria Canela

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