Metabolomic and Lipidomic Profiling of Preoperative CSF in Elderly Hip Fracture Patients With Postoperative Delirium

Frontiers in Aging Neuroscience
Yongzheng HanYi Yuan

Abstract

To investigate dysregulated molecules in preoperative cerebrospinal fluid (CSF) of elderly hip fracture patients with postoperative delirium (POD), in order to identify potential pathological mechanisms and biomarkers for pre-stage POD. This nested case control study used untargeted metabolomic and lipidomic analysis to profile the preoperative CSF of patients (n = 40) who developed POD undergone hip fracture surgery (n = 10) and those who did not (n = 30). Thirty Non-POD patients were matched to 10 POD patients by age (± 2 years) and Mini Mental State Examination score (± 2 points). CSF was collected after successful spinal anesthesia and banked for subsequent analysis. On the first two postoperative days, patients were assessed twice daily using the Confusion Assessment Method-Chinese Revision. CSF samples from the two groups were analyzed to investigate possible relevant pathological mechanisms and identify candidate biomarkers. Demographic characteristics of the groups were matched. Eighteen metabolites and thirty-three lipids were dysregulated in the preoperative CSF of POD patients. Pathway enrichment analysis revealed perturbations in D-glutamine and D-glutamate metabolism; glycerophospholipid metabolism; alanine, aspart...Continue Reading

References

May 1, 1984·Journal of Neurosurgery·B K Siesjö
Sep 25, 2002·Journal of Neuroscience Research·Rao Muralikrishna Adibhatla, J F Hatcher
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Roy G CutlerMark P Mattson
May 6, 2008·Neurobiology of Aging·Michelle M MielkeMichelle C Carlson
Jul 8, 2010·Nature Reviews. Molecular Cell Biology·Andrej Shevchenko, Kai Simons
Apr 9, 2011·Anesthesia and Analgesia·James L Rudolph, Edward R Marcantonio
Sep 25, 2012·Journal of the American Medical Directors Association·Eva M SchmittUNKNOWN SAGES Study Group
Sep 3, 2013·Lancet·Sharon K InouyeJane S Saczynski
Nov 12, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·José R Maldonado
Mar 13, 2014·Nature Medicine·Mark MapstoneHoward J Federoff
Apr 10, 2014·Molecular BioSystems·Martina WallaceLorraine Brennan
May 6, 2015·Nature Methods·Hiroshi TsugawaMasanori Arita
Aug 20, 2015·Current Neurovascular Research·Masoumeh FaeziAlireza Ghasempour
Apr 23, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sharon K InouyeRichard N Jones
Apr 30, 2016·Journal of Alzheimer's Disease : JAD·Farida El GaamouchDongming Cai
May 11, 2016·Journal of Alzheimer's Disease : JAD·Hanzhi LiZhiqiang Yang
Oct 19, 2016·Nature Reviews. Neuroscience·Laszlo Vutskits, Zhongcong Xie
Feb 10, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yong GuoWei Jiang
Feb 12, 2017·European Journal of Anaesthesiology·César AldecoaClaudia D Spies
May 6, 2017·Current Alzheimer Research·Amira ZarroukGerard Lizard
Jul 26, 2017·Annals of Surgery·Julia R BerianThomas N Robinson
Jun 6, 2019·Anesthesiology·Lori A DaielloUNKNOWN SAGES Study Group*
Dec 14, 2019·Anesthesiology·Roderic G EckenhoffMaryellen F Eckenhoff
Apr 9, 2020·Frontiers in Cellular Neuroscience·Denisa Belov KirdajovaMiroslava Anderova

❮ Previous
Next ❯

Citations

Jun 8, 2021·Frontiers in Aging Neuroscience·Yuxiang SongWeidong Mi
Aug 14, 2021·Clinical & Translational Immunology·Jingya YanShanlin Fu

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
coronary artery bypass

Software Mentioned

Metaboanalyst
PCA
MS
DA
PLS
DIAL
SPSS

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2021 Meta ULC. All rights reserved