Metabolomic applications to decipher gut microbial metabolic influence in health and disease.

Frontiers in Physiology
François-Pierre J MartinSunil Kochhar

Abstract

Dietary preferences and nutrients composition have been shown to influence human and gut microbial metabolism, which ultimately has specific effects on health and diseases' risk. Increasingly, results from molecular biology and microbiology demonstrate the key role of the gut microbiota metabolic interface to the overall mammalian host's health status. There is therefore raising interest in nutrition research to characterize the molecular foundations of the gut microbial-mammalian cross talk at both physiological and biochemical pathway levels. Tackling these challenges can be achieved through systems biology approaches, such as metabolomics, to underpin the highly complex metabolic exchanges between diverse biological compartments, including organs, systemic biofluids, and microbial symbionts. By the development of specific biomarkers for prediction of health and disease, metabolomics is increasingly used in clinical applications as regard to disease etiology, diagnostic stratification, and potentially mechanism of action of therapeutical and nutraceutical solutions. Surprisingly, an increasing number of metabolomics investigations in pre-clinical and clinical studies based on proton nuclear magnetic resonance ((1)H NMR) spect...Continue Reading

Citations

Jan 15, 2013·Pediatric Research·Sofia MocoFrançois-Pierre J Martin
Nov 26, 2013·Mechanisms of Ageing and Development·Sebastiano CollinoElizabeth Offord
Jan 10, 2013·Annual Review of Food Science and Technology·Sandrine P Claus, Jonathan R Swann
Jul 16, 2013·Journal of Digestive Diseases·Cheng Gong Yu, Qin Huang
May 2, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Almut Heinken, Ines Thiele
Aug 25, 2015·Frontiers in Molecular Biosciences·Peter SperisenFrançois-Pierre J Martin
Sep 27, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gavino FaaVassilios Fanos
Jul 31, 2013·Current Opinion in Microbiology·Peter van BaarlenJerry M Wells
Mar 26, 2014·Mechanisms of Ageing and Development·Sebastiano CollinoElizabeth Offord
Nov 10, 2013·PloS One·Luis Caetano M AntunesNicolas Carels
Aug 11, 2016·Frontiers in Microbiology·Pamela VernocchiLorenza Putignani
Apr 21, 2017·Frontiers in Microbiology·Theresa Wan-Chen YapJamuna Vadivelu
Jul 17, 2014·Inflammatory Bowel Diseases·Sofia MocoFrancois-Pierre J Martin
Dec 1, 2017·Briefings in Bioinformatics·Aitor Blanco-MíguezAnália Lourenço
Nov 13, 2012·Journal of Bacteriology·Vic NorrisAndrew T Gewirtz
Apr 29, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Neerja HajelaNirmal K Ganguly
Aug 12, 2016·The American Journal of Clinical Nutrition·Mary C PlaydonSteven C Moore
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Apr 1, 2021·Cell Metabolism·Diana E Gutierrez LopezMolly S Bray
Mar 10, 2015·Journal of Proteome Research·Francois-Pierre J MartinJalil Benyacoub

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Methods Mentioned

BETA
genetic modifications
biopsies
nuclear magnetic resonance
biopsy
gastric bypass
NMR

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