Metabolomic composition of normal aged and cataractous human lenses

Experimental Eye Research
Yuri P TsentalovichRenad Z Sagdeev

Abstract

Quantitative metabolomic profiles of normal and cataractous human lenses were obtained with the combined use of high-frequency nuclear magnetic resonance (NMR) and high-performance liquid chromatography with high-resolution mass-spectrometric detection (LC-MS) methods. The concentration of more than fifty metabolites in the lens cortex and nucleus has been determined. For the majority of metabolites, their concentrations in the lens cortex and nucleus are similar, which confirms low metabolic activity in the lens core. The difference between the metabolite levels in the cortex and nucleus of the normal lens is observed for antioxidants and UV filters, which demonstrates the activity of redox processes in the lens. A huge difference is found between the metabolomic compositions of normal and age-matched cataractous lenses: the concentrations of almost all metabolites in the normal lens are higher than in the cataractous one. The most pronounced difference is observed for compounds playing a key role in the lens cell protection and metabolic activity, including antioxidants, UV filters, and osmolytes. The results obtained imply that the development of the age-related cataracts might originate from the metabolic dysfunction of the...Continue Reading

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Citations

Oct 27, 2015·Experimental Eye Research·Semen O TamaraYuri P Tsentalovich
Mar 20, 2016·Experimental Eye Research·Deepti Anand, Salil A Lachke
Jan 12, 2016·Physical Chemistry Chemical Physics : PCCP·P S SherinYu P Tsentalovich
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Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Vadim V YansholeYuri P Tsentalovich
May 28, 2019·Metabolomics : Official Journal of the Metabolomic Society·Olga A SnytnikovaYuri P Tsentalovich
Jul 22, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Neshe Nazifova-TasinovaChristina Grupcheva
Jul 3, 2020·Metabolomics : Official Journal of the Metabolomic Society·Ekaterina A ZelentsovaYuri P Tsentalovich
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Oct 15, 2020·Scientific Reports·Yuri P TsentalovichIliya M Odud
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Nov 8, 2020·Experimental Eye Research·Shahid Y KhanS Amer Riazuddin
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anastasia GlinskikhAndrey Akulov
Aug 2, 2021·Experimental Eye Research·Eugene SerebryanyLiliana Quintanar

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