Metabolomic profiles indicate distinct physiological pathways affected by two loci with major divergent effect on Bos taurus growth and lipid deposition

Physiological Genomics
R WeikardC Kühn

Abstract

Identifying trait-associated genetic variation offers new prospects to reveal novel physiological pathways modulating complex traits. Taking advantage of a unique animal model, we identified the I442M mutation in the non-SMC condensin I complex, subunit G (NCAPG) gene and the Q204X mutation in the growth differentiation factor 8 (GDF8) gene as substantial modulators of pre- and/or postnatal growth in cattle. In a combined metabolomic and genotype association approach, which is the first respective study in livestock, we surveyed the specific physiological background of the effects of both loci on body-mass gain and lipid deposition. Our data provided confirming evidence from two historically and geographically distant cattle populations that the onset of puberty is the key interval of divergent growth. The locus-specific metabolic patterns obtained from monitoring 201 plasma metabolites at puberty mirror the particular NCAPG I442M and GDF8 Q204X effects and represent biosignatures of divergent physiological pathways potentially modulating effects on proportional and disproportional growth, respectively. While the NCAPG I442M mutation affected the arginine metabolism, the 204X allele in the GDF8 gene predominantly raised the car...Continue Reading

References

Feb 1, 1975·Journal of Animal Science·K A Barber, J O Almquist
Nov 1, 1996·The American Journal of Physiology·G WuS P Flynn
Sep 8, 2000·The Journal of Biological Chemistry·M ThomasR Kambadur
Apr 10, 2002·American Journal of Physiology. Cell Physiology·Ramón RíosJesús Devesa
Jun 11, 2002·Annual Review of Nutrition·Guoyao Wu, Cynthia J Meininger
Sep 24, 2002·The Journal of Biological Chemistry·Brett LangleyRavi Kambadur
Jan 18, 2003·Biochimica Et Biophysica Acta·Zheng Cui, Martin Houweling
Feb 28, 2003·Genetics, Selection, Evolution : GSE·Susana DunnerFrançois Ménissier
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Junghee LeeRajiv R Ratan
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Feb 19, 2004·Nature Reviews. Genetics·Leif Andersson, Michel Georges
May 29, 2004·Bioinformatics·M Pérez-Enciso, I Misztal
May 4, 2005·Molecular Cell·Mark T Bedford, Stéphane Richard
Jul 30, 2005·Nature Reviews. Drug Discovery·Markus R Wenk
Jun 13, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan T KielsteinDanilo Fliser
Aug 8, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Patrick BulauOliver Eickelberg
Aug 2, 2007·American Journal of Physiology. Endocrinology and Metabolism·Vitor A LiraDavid S Criswell
Oct 12, 2007·Diabetes Care·Sangeeta R KashyapRalph A DeFronzo
Apr 9, 2008·Nature Genetics·Daniel F GudbjartssonKari Stefansson
Apr 9, 2008·Nature Genetics·Michael N WeedonTimothy M Frayling
Sep 16, 2008·Therapeutische Umschau. Revue thérapeutique·Klaus M Weinberger
Oct 18, 2008·The Journal of Nutritional Biochemistry·Robert RingseisKlaus Eder
Nov 26, 2008·Amino Acids·Guoyao WuYulong Yin
Aug 25, 2009·Atherosclerosis·Friedrich SchulzeRainer H Böger
Sep 30, 2009·Nature Reviews. Endocrinology·Michael E SymondsHelen Budge
Oct 7, 2009·Advances in Clinical Chemistry·Arduino A Mangoni
Oct 13, 2009·The Journal of Biological Chemistry·Arthur J PopeArturo J Cardounel

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Citations

Aug 12, 2015·Animal Science Journal = Nihon Chikusan Gakkaihō·Akiko Takasuga
Aug 4, 2015·Archives of Biochemistry and Biophysics·Marc Breit, Klaus M Weinberger
Apr 14, 2012·Animal Genetics·B Gutiérrez-GilC S Haley
May 8, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Aline JelenkovicKarri Silventoinen
May 4, 2015·BMC Genetics·Goutam SahanaMogens S Lund
May 23, 2017·PloS One·Seyed Ali GoldansazDavid S Wishart
Jul 31, 2018·Animal Genetics·S LyuG A Brockmann
Jan 31, 2019·PloS One·Artur GurgulMonika Bugno-Poniewierska
Aug 11, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jiafei ShenRuihua Dang
Oct 26, 2021·Frontiers in Veterinary Science·Chongyu ZhangYunkyoung Lee

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