Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP

Cardiovascular Diabetology
Annette MasuchNele Friedrich

Abstract

The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is an important biomarker for the diagnosis of heart failure. Apart from this and only recently recognized, NT-proBNP levels associate with higher HDL- and lower LDL-cholesterol levels comprising a favorable blood lipid profile. To further examine this observation, the lipoprotein profile in relation to NT-proBNP was examined in-depth by proton nuclear magnetic resonance spectroscopy (1H-NMR). We complemented this investigation with a state-of-the-art untargeted metabolomics approach. Lipoprotein particles were determined by 1H-NMR spectroscopy in 872 subjects without self-reported diabetes from the population-based Study of Health in Pomerania (SHIP)-TREND with available NT-proBNP measurements. Comprehensive metabolomics data for plasma and urine samples were obtained. Linear regression models were performed to assess the associations between serum concentrations of NT-proBNP and the metabolites/lipoprotein particles measured in plasma or urine. An increase in serum NT-proBNP was associated with a benefical lipoprotein profile, including a decrease in VLDL, IDL and LDL-particles along with an increase in large HDL particles. These findings were replicated in a ...Continue Reading

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Citations

Aug 16, 2019·Cardiovascular Diabetology·Zengliang WangShuo Wang
Sep 12, 2020·Future Cardiology·Hubert MadoBożena Szyguła-Jurkiewicz
Feb 19, 2021·Scientific Reports·Sowmya CharyKenneth B Christopher
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Dec 6, 2020·Annales d'endocrinologie·Nathalie GilliéronUrs E Nydegger

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Methods Mentioned

BETA
nuclear magnetic resonance
enzyme-linked immunosorbent assay

Software Mentioned

R package
R
SAS
R Foundation

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