Metabolomic profiling in colorectal cancer: opportunities for personalized medicine

Personalized Medicine
Xiaojiao ZhengWei Jia

Abstract

Colorectal cancer (CRC) is one of the most common types of cancer in the world, with high prevalence and mortality. Understanding the alterations of cancer metabolism and identifying reliable biomarkers would facilitate the development of novel technologies of CRC screening and early diagnosis, as well as new approaches to providing personalized medicine. Metabolomics, as an emerging molecular phenotyping approach, provides a clinical platform technology with an unprecedented amount of metabolic readout information, which is ideal for theranostic biomarker discovery. Metabolic signatures can link the unique pathophysiological states of patients to personalized health monitoring and intervention strategies. This article presents an overview of the metabolomic studies of CRC with a focus on recent advances in the biomarker discovery in serum, urine, fecal water and tissue samples for cancer diagnosis. The development and application of metabolomics towards personalized medicine, including early diagnosis, cancer staging, treatment and drug discovery are also discussed.

References

Oct 1, 1995·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·A Hague, C Paraskeva
Jan 31, 1998·Chemistry & Biology·C A HassigS L Schreiber
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·E A ThomasJ G Sutcliffe
Mar 13, 1998·Gastroenterology·Q Aziz, D G Thompson
Aug 14, 1999·International Journal of Cancer. Journal International Du Cancer·S BackertC Hanski
Feb 13, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen G Oliver
Jun 4, 2002·Nature Medicine·Maurizio Bifulco, Vincenzo Di Marzo
Nov 8, 2002·British Medical Bulletin·Nicola S FearnheadWalter F Bodmer
Feb 24, 1956·Science·O WARBURG
Mar 5, 2004·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Desmond LeddinUNKNOWN Canadian Digestive Health Foundation
Apr 24, 2004·Mechanisms of Ageing and Development·Wulf Dröge
May 14, 2004·Cellular and Molecular Life Sciences : CMLS·U J RoblickH Jörnvall
Jul 2, 2004·Nature Reviews. Cancer·Julian L Griffin, John P Shockcor
Jul 9, 2005·Nature Biotechnology·John C LindonUNKNOWN Standard Metabolic Reporting Structures working group
Jul 13, 2005·Gut·N Andre, W Schmiegel
Jul 27, 2005·Biochemical Society Transactions·S ChellC Paraskeva
Aug 4, 2005·Journal of the National Cancer Institute·Wei-Dong ChenSanford D Markowitz
Sep 27, 2005·The American Journal of Gastroenterology·Wai K LeungJoseph J Y Sung
Oct 28, 2005·Mini Reviews in Medicinal Chemistry·Natalya M Kogan
Dec 13, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Edward AbrahamsMike Silver
Jan 28, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Roberto MazzantiCecilia Giulivi
Jun 7, 2006·British Journal of Cancer·D G WardA Martin
Feb 22, 2007·Annual Review of Nutrition·Noboru Mizushima, Daniel J Klionsky
Dec 7, 2007·Journal of Proteome Research·Jasmina SaricElaine Holmes
Jan 11, 2008·Annual Review of Pharmacology and Toxicology·Rima Kaddurah-DaoukRichard M Weinshilboum
Mar 4, 2008·Gastroenterology Clinics of North America·James R Marshall
Nov 14, 2008·NMR in Biomedicine·Daniel MonleónBernardo Celda
Jan 14, 2009·Rapid Communications in Mass Spectrometry : RCM·Mainak MalEric Chun Yong Chan
Feb 26, 2009·The American Journal of Gastroenterology·Douglas K RexUNKNOWN American College of Gastroenterology
Jul 28, 2009·Annual Review of Medicine·Miles BergerBryan L Roth
Aug 15, 2009·Journal of Proteome Research·Yunping QiuWei Jia

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Citations

Nov 18, 2018·Frontiers of Medicine·Xiaojiao ZhengWei Jia

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Methods Mentioned

BETA
biopsies
nuclear magnetic resonance
metabolomic profiling
electrophoresis
surgical resection
laser capture microdissection
NMR

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