Jan 24, 2020

Metabolomic profiling of metoprolol-induced cardioprotection in a murine model of acute myocardial ischemia

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Qiong LaiFang Li

Abstract

Metoprolol (Met) is widely applied in the treatment of myocardial infarction and coronary heart disease in clinic. However, the metabolic network in vivo affected by Met manipulation is still unclear and it's therapeutic molecular mechanisms were remained to be furthered elucidated except β1 adrenergic receptor. Myocardial infarction (MI) was induced by permanent CAL for 24 h in ICR mice. Myocardial infarct size, biochemical indicators such as creatine kinase (CK), lactate dehydrogenase (LDH), C-reactive Protein (CRP), tumor necrosis factor-α (TNF-α) and cardiac troponin I(cTn-I), cardiac function and myocardial pathological changes were detected to ensure the improvement of Met on MI. Subsequently, the significantly changed endogenous metabolites and the network in both serum and urine were screened and constructed through metabolomics by using HPLC-Q-TOF/MS. Finally, the potential regulatory enzymes that could be the possible new therapeutic targets of Met were selected and validated by western blotting and immunohistochemistry based on the screened differential metabolites and the enrichment analysis. Met effectively reduced the infarct size of myocardial infarction mice, improved the biochemical indicators, and ameliorated ...Continue Reading

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Mentioned in this Paper

Myocardium
Cysteine
Creatine Kinase
Metabolite
Arginine: Glycine Amidinotransferase Deficiency
Coronary Heart Disease
Methionine
Metabolomics
Metoprolol
Myocardial Infarction

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