Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences

Radiation Research
Evagelia C LaiakisAlbert J Fornace

Abstract

As space travel is expanding to include private tourism and travel beyond low-Earth orbit, so is the risk of exposure to space radiation. Galactic cosmic rays and solar particle events have the potential to expose space travelers to significant doses of radiation that can lead to increased cancer risk and other adverse health consequences. Metabolomics has the potential to assess an individual's risk by exploring the metabolic perturbations in a biofluid or tissue. In this study, C57BL/6 mice were exposed to 0.5 and 2 Gy of 1 GeV/nucleon of protons and the levels of metabolites were evaluated in urine at 4 h after radiation exposure through liquid chromatography coupled to time-of-flight mass spectrometry. Significant differences were identified in metabolites that map to the tricarboxylic acid (TCA) cycle and fatty acid metabolism, suggesting that energy metabolism is severely impacted after exposure to protons. Additionally, various pathways of amino acid metabolism (tryptophan, tyrosine, arginine and proline and phenylalanine) were affected with potential implications for DNA damage repair and cognitive impairment. Finally, presence of products of purine and pyrimidine metabolism points to direct DNA damage or increased apop...Continue Reading

References

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Citations

Nov 17, 2015·Expert Review of Molecular Diagnostics·Vijay K SinghHarvey B Pollard
Apr 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruin MoaddelLuigi Ferrucci
Feb 23, 2017·Molecular BioSystems·Mingxiao ZhaoChang Wang
May 6, 2017·Radiation Research·Evagelia C LaiakisAlbert J Fornace
Dec 13, 2019·International Journal of Radiation Biology·Gabriela KultovaAlena Myslivcova-Fucikova
Aug 17, 2020·Metabolites·Merriline M SatyamitraAndrea L DiCarlo
Apr 4, 2021·International Journal of Molecular Sciences·Evagelia C LaiakisMark R Emmett
Apr 28, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Michael GirgisAmrita K Cheema
May 16, 2019·Journal of Proteome Research·Alexandra TarabolettiFrederic Zenhausern

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Methods Mentioned

BETA
metabolomic profiling
X-ray

Software Mentioned

Progenesis QI
MetaboLyzer
Progenesis QI Informatics
GEDI
METLIN
Gene Expressions Dynamics Inspector ( GEDI )
SIMCA

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