Abstract
As space travel is expanding to include private tourism and travel beyond low-Earth orbit, so is the risk of exposure to space radiation. Galactic cosmic rays and solar particle events have the potential to expose space travelers to significant doses of radiation that can lead to increased cancer risk and other adverse health consequences. Metabolomics has the potential to assess an individual's risk by exploring the metabolic perturbations in a biofluid or tissue. In this study, C57BL/6 mice were exposed to 0.5 and 2 Gy of 1 GeV/nucleon of protons and the levels of metabolites were evaluated in urine at 4 h after radiation exposure through liquid chromatography coupled to time-of-flight mass spectrometry. Significant differences were identified in metabolites that map to the tricarboxylic acid (TCA) cycle and fatty acid metabolism, suggesting that energy metabolism is severely impacted after exposure to protons. Additionally, various pathways of amino acid metabolism (tryptophan, tyrosine, arginine and proline and phenylalanine) were affected with potential implications for DNA damage repair and cognitive impairment. Finally, presence of products of purine and pyrimidine metabolism points to direct DNA damage or increased apop...Continue Reading
References
May 7, 1998·Life Sciences·A A PapamandjarisP J Jones
May 3, 2005·Behavioural Brain Research·Tara L MooreDouglas L Rosene
Dec 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·C Di PietroM Purrello
Apr 4, 2007·Annals of the New York Academy of Sciences·Aleksandra M Ristic-FiraGiacomo Cuttone
May 22, 2007·The Journal of Nutrition·Keith Hyland
Jan 5, 2008·Analytical Chemistry·Andrew D PattersonJeffrey R Idle
Jun 28, 2008·Radiation Research·John B TyburskiJeffrey R Idle
Jul 8, 2009·Radiation Research·John B TyburskiJeffrey R Idle
May 22, 2010·Radiation and Environmental Biophysics·Daniela TraniAlbert J Fornace
Oct 20, 2010·International Journal of Radiation Biology·Ariungerel GerelchuluunKoji Tsuboi
Feb 16, 2011·Radiation Research·Manuela BuonannoEdouard I Azzam
Dec 2, 2011·Radiation Research·Evagelia C LaiakisAlbert J Fornace
Sep 1, 2012·PloS One·Kamal DattaAlbert J Fornace
Feb 5, 2013·Radiation Research·Swati GirdhaniLynn Hlatky
Apr 5, 2013·PloS One·Kamal DattaAlbert J Fornace
Oct 23, 2013·PloS One·Francis A CucinottaJanice L Huff
Nov 26, 2013·Analytical Chemistry·Tytus D MakAlbert J Fornace
Jan 22, 2014·Brain Structure & Function·Vipan K PariharCharles L Limoli
Jan 30, 2014·PloS One·Amrita K CheemaKamal Datta
Feb 12, 2014·Radiation Research·Daniela TraniAlbert J Fornace
Mar 13, 2014·Radiation Research·Catherine M DavisRobert D Hienz
Mar 29, 2014·Radiation Research·Evagelia C LaiakisAlbert J Fornace
Sep 27, 2014·Life Sciences in Space Research·Ann R Kennedy
Oct 23, 2014·PloS One·Xinhua YanDavid A Goukassian
Nov 6, 2014·Life·Jeffery C ChancellorJeffrey P Sutton
Citations
Nov 17, 2015·Expert Review of Molecular Diagnostics·Vijay K SinghHarvey B Pollard
Apr 5, 2016·Mutation Research·Evagelia C LaiakisAlbert J Fornace
Apr 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruin MoaddelLuigi Ferrucci
Feb 23, 2017·Molecular BioSystems·Mingxiao ZhaoChang Wang
May 6, 2017·Radiation Research·Evagelia C LaiakisAlbert J Fornace
Dec 1, 2018·Biomedical Chromatography : BMC·Xueting YaoChang Wang
Sep 22, 2019·Medicina·Keywan MortezaeeAhmed Eleojo Musa
Dec 13, 2019·International Journal of Radiation Biology·Gabriela KultovaAlena Myslivcova-Fucikova
Aug 17, 2020·Metabolites·Merriline M SatyamitraAndrea L DiCarlo
Sep 26, 2019·Frontiers in Molecular Biosciences·Eileen Ruth S TorresJacob Raber
Apr 4, 2021·International Journal of Molecular Sciences·Evagelia C LaiakisMark R Emmett
Apr 28, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Michael GirgisAmrita K Cheema
Jul 10, 2016·Journal of the American Society for Mass Spectrometry·Zhidan ChenPaul Vouros
Mar 23, 2019·Analytical Chemistry·Deying ChenLanjuan Li
May 16, 2019·Journal of Proteome Research·Alexandra TarabolettiFrederic Zenhausern