Metabolomics analysis and biological investigation of three Malvaceae plants

Phytochemical Analysis : PCA
Omnia Hesham AbdelhafezUsama Ramadan Abdelmohsen

Abstract

Metabolomics is a fast growing technology that has effectively contributed to many plant-related sciences and drug discovery. To use the non-targeted metabolomics approach to investigate the chemical profiles of three Malvaceae plants, namely Hibiscus mutabilis L. (Changing rose), H. schizopetalus (Dyer) Hook.f. (Coral Hibiscus), and Malvaviscus arboreus Cav. (Sleeping Hibiscus), along with evaluating their antioxidant and anti-infective potential. Metabolic profiling was carried out using liquid chromatography coupled with high-resolution electrospray ionisation mass spectrometry (LC-HR-ESI-MS) for dereplication purposes. The chemical composition of the studied plants was further compared by principal component analysis (PCA). The antioxidant and anti-infective properties of their different extracts were correlated to their phytochemical profiles by orthogonal partial least square discriminant analysis (OPLS-DA). A variety of structurally different metabolites, mostly phenolics, were characterized. Comparing the distribution pattern of these tentatively identified metabolites among the studied plant species/fractions revealed the chemical uniqueness of the dichloromethane fraction of M. arboreus. Some extracts and fractions of...Continue Reading

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Citations

May 8, 2020·Marine Drugs·Reda F A AbdelhameedUsama Ramadan Abdelmohsen
Nov 5, 2020·Antibiotics·Riham A El-ShiekhRehab M Ashour
Feb 10, 2021·Chemistry & Biodiversity·Sergio Rodríguez-MoralesOswaldo Hernández-Abreu
Aug 11, 2021·Plants·Deyani Nocedo-MenaMaría Del Rayo Camacho-Corona

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