Abstract
Most paraquat (PQ) poisoned patients died from acute multiple organ failure (MOF) such as lung, kidney, and heart. However, the exact mechanism of intoxication is still unclear. In order to find out the initial toxic mechanism of PQ poisoning, a blood metabolomics study based on ultraperformance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and efficient machine learning approach was performed on 23 PQ poisoned patients and 29 healthy subjects. The initial PQ plasma concentrations of PQ poisoned patients were >1000 ng/mL, and the blood samples were collected at before first hemoperfusion (HP), after first HP, and after last HP. The results showed that PQ poisoned patients all differed from healthy subjects, whatever they were before or after first HP or after last HP. The efficient machine learning approaches selected key metabolites from three UPLC/Q-TOF-MS data sets which had the highest classification performance in terms of classification accuracy, Matthews Correlation Coefficients, sensitivity, and specificity, respectively. The mass identification revealed that the most important metabolite was adenosine, which sustained in low level, regardless of whether PQ poisoned patient...Continue Reading
References
May 26, 2004·Brain Research·Rosa A González-PoloJosé M Fuentes
Aug 2, 2007·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Runxuan ZhangP Saratchandran
Sep 28, 2010·Clinical Biochemistry·Juanwen ZhangYing Zhao
Feb 3, 2011·Journal of Medical Systems·Hui-Ling ChenDa-You Liu
Apr 5, 2011·Analytica Chimica Acta·Hongcui CaoLanjuan Li
Dec 29, 2012·PloS One·Cheng-Hao WengTzung-Hai Yen
Jun 21, 2013·IEEE Transactions on Cybernetics·Yalda MohsenzadehMahdi M Kalayeh
Feb 20, 2015·BioMed Research International·Lufeng HuZhongqiu Lu
Feb 24, 2015·Computers in Biology and Medicine·Lufeng HuHuiling Chen
Mar 12, 2015·Biological & Pharmaceutical Bulletin·Xianqin WangLufeng Hu
Mar 17, 2015·Scientific Reports·JuanWen ZhangYu Chen
Apr 29, 2015·Journal of Proteome Research·Yubo LiYanjun Zhang
Nov 26, 2015·PloS One·Huiling ChenLufeng Hu
May 20, 2016·Scientific Reports·Pengcheng ZhouLanjuan Li
May 25, 2016·Journal of Pharmacological and Toxicological Methods·Guangliang HongZhongqiu Lu
Jun 10, 2016·International Journal of Experimental Pathology·Rômulo D NovaesAntônio J Natali
Jul 25, 2017·Computer Methods and Programs in Biomedicine·Jianfu XiaHong Zhou
Oct 22, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zhenning LiuMin Zhao
Nov 4, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Indika GawarammanaAndrew H Dawson
Dec 24, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fateme PourgholamhosseinAli Mandegary
Jul 12, 2018·IEEE Journal of Biomedical and Health Informatics·Haijun LeiBaiying Lei
Aug 5, 2018·Psychoneuroendocrinology·Carisha S ThesingBrenda W J H Penninx