Metabolomics and its application for non-invasive embryo assessment in IVF.

Molecular Human Reproduction
Lucy BotrosEmre Seli

Abstract

Morphology and cleavage rate remain the mainstay of embryo assessment. However, a number of additional technologies for this application are under investigation. These include the measurement of glucose, lactate, pyruvate or amino acid levels in the embryo culture media, assessment of oxygen consumption by the embryo, genomic and proteomic profiling, and most recently, analytical examination of the embryonic metabolome. As the number of assisted reproduction cycles increases worldwide, improvements in the ability to quickly and non-invasively identify the best embryos for transfer remain a critical goal for reproductive medicine. Recent studies suggest that metabolomic profiling of embryo culture media using optical and non-optical spectroscopies may provide a useful adjunct to the current embryo assessment strategies and provide insight into the phenotype of embryos with increasing reproductive potential.

References

Aug 12, 1978·Lancet·P C Steptoe, R G Edwards
Aug 12, 1978·Lancet·D W Evans
Apr 1, 1987·The Journal of Experimental Zoology·D K Gardner, H J Leese
Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J D BiggersR P Donahue
Mar 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·R G EdwardsJ M Webster
Sep 1, 1993·Journal of Reproduction and Fertility·J ConaghanH J Leese
Jan 1, 1993·Journal of Assisted Reproduction and Genetics·J ConaghanH J Leese
Jul 18, 2000·The Journal of Hospital Infection·N P O'Sullivan, C T Keane
Apr 2, 2002·Human Reproduction·Franchesca D HoughtonHenry J Leese
Jul 18, 2002·Nature Reviews. Drug Discovery·Jeremy K NicholsonElaine Holmes
Mar 17, 2004·Clinical Obstetrics and Gynecology·Barbara Luke, Joyce A Martin
Feb 1, 2005·Journal of Natural Products·Guido F PauliDavid C Lankin
Feb 1, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ian D WilsonEva M Lenz
May 5, 2005·Current Opinion in Obstetrics & Gynecology·Denny Sakkas, David K Gardner
Aug 22, 2006·Mass Spectrometry Reviews·Katja DettmerBruce D Hammock
Sep 6, 2006·Fertility and Sterility·Mandy G Katz-JaffeDavid K Gardner
Mar 23, 2007·Journal of Chromatography. a·Maria Rowena N Monton, Tomoyoshi Soga
Nov 7, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xin LuGuowang Xu
May 16, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kishore K PasikantiE C Y Chan
Oct 7, 2008·Human Reproduction·Roger G SturmeyHenry J Leese

❮ Previous
Next ❯

Citations

Apr 9, 2013·Molecular Aspects of Medicine·Anna Ajduk, Magdalena Zernicka-Goetz
Jun 24, 2010·Cell Stem Cell·Kouichi HasegawaMartin F Pera
Apr 10, 2012·Journal of Natural Products·Guido F PauliDavid C Lankin
Oct 2, 2013·Human Reproduction Update·Signe AltmäeAndres Salumets
Jun 12, 2010·Molecular Human Reproduction·Emre SeliMarc-Andre Sirard
Oct 12, 2013·Molecular Human Reproduction·Stephen G Hillier
Dec 4, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Donald G RobertsonMichael D Reily
May 6, 2009·Reproductive Biology and Endocrinology : RB&E·Alberto RevelliPaolo Rinaudo
Jul 28, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·A O'GormanL Brennan
Feb 14, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Sylvia Sanches CortezziEdson Borges
Jun 27, 2014·Journal of Assisted Reproduction and Genetics·Varshini JayaramanPratap Kumar Narayan
May 3, 2014·Journal of Assisted Reproduction and Genetics·Einat ZiviYoel Shufaro
Jun 22, 2014·Gynécologie, obstétrique & fertilité·L AlterC Sifer
Nov 17, 2010·Cellular and Molecular Life Sciences : CMLS·Roberta RizzoVera Rebmann
May 28, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroChris Beecher
Jan 26, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Burcu Aydin BoyamaPelin Ocal
May 21, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong-Kyu LeeJeongmi Lee
Aug 13, 2013·Reproductive Biomedicine Online·Markus MontagThomas Strowitzki
Jun 12, 2012·Reproductive Biomedicine Online·Rachel Brown, Joyce Harper
Jul 12, 2011·Fertility and Sterility·Sivakumar RamuRajasingam S Jeyendran
Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·F LamazouN Achour-Frydman
Sep 19, 2015·Reproductive Biomedicine Online·Tina RødgaardHenrik Callesen
Apr 22, 2011·Molecular Reproduction and Development·Wiem RekikMarc-André Sirard
Aug 3, 2011·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Deirdre L Zander-FoxMichelle Lane
Nov 21, 2013·Molecular Reproduction and Development·Kambiz GilanyElham Savadi-Shiraz
Jan 9, 2015·Human Reproduction Update·David K GardnerNathan R Treff
Aug 19, 2015·Reproductive Biomedicine Online·Kersti Lundin, Aisling Ahlström
Jun 15, 2011·Reproductive Biomedicine Online·Sarah NordqvistHelena Akerud
Mar 15, 2011·Reproductive Biomedicine Online·Aisling AhlströmThorir Hardarson

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
nuclear magnetic resonance
electrophoresis
circular dichroism
metabolomic profiling

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.