Metabolomics and Lipidomics Approaches in the Science of Probiotics: A Review

Journal of Medicinal Food
Hyuk-Jin ChungHyung-Kyoon Choi

Abstract

The intestinal microflora plays important roles in the health of the host, such as nutrient processing and the modulation of intestinal immune responses. The constituents of the diet greatly affect the composition of the microbiota and its metabolites. The human intestinal microbiota is made up of around 100 trillion microbial cells encompassing at least 300 species. Consuming probiotics may lead to changes in the intestinal microflora that influence host health. Metabolomics is a powerful tool for revealing metabolic changes in biofluids, tissues, and organs of hosts induced by the consumption of probiotics, and lipidomics in particular is a technical approach that focuses on the analysis of lipids in various cells and biofluids. Metabolomics and lipidomics have been used to investigate intracellular and extracellular metabolites as well as for the nontargeted profiling and fingerprinting of metabolites. Based on metabolomics and lipidomics investigations, we reviewed the effects of consuming probiotics on metabolic profiles in controlled intestinal environments. We also discuss the associations between metabolic changes and human diseases after consuming probiotics in uncontrolled intestinal environments. In addition, we revi...Continue Reading

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Citations

Jun 5, 2019·Journal of Cellular and Molecular Medicine·Rong LiXiaoxi Zhang
Aug 19, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Helena TranPanayiotis Loukopoulos
May 23, 2019·Future Science OA·Richard Lj DayLiam M Heaney
Sep 3, 2020·Applied Microbiology and Biotechnology·Emily SchifanoDaniela Uccelletti
Jan 24, 2019·Heliyon·Marta Anna SzychlinskaGiuseppe Musumeci
Apr 23, 2021·Genes & Nutrition·Katherine J LiEdith J M Feskens
Apr 1, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuying LiuJ Marc Rhoads

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

MVDA

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