Metabolomics and proteomics approaches to characterize and assess proteins of bear bile powder for hepatitis C virus

Chinese Journal of Natural Medicines
Xijun WangYun Chen

Abstract

Metabolomics represents an emerging and powerful discipline that provides an accurate and dynamic picture of the phenotype of bio-systems through the study of potential metabolites that could be used as therapeutic targets and for the discovery of new drugs. Hepatitis C virus (HCV) is a leading cause of liver disease worldwide, and is a major burden on public health. It is hypothesized that an animal model of HCV infection would produce unique patterns of endogenous metabolites. Herein, a method for the construction of efficient networks is presented with regard to the proteins of bear bile powder (PBBP) that protect against HCV as a case study. Ultra-performance liquid chromatography, coupled with electrospray ionization/quadrupole-time-of-flight high definition mass spectrometry (UPLC-HDMS), coupled with pattern recognition methods and computational systems analysis were integrated to obtain comprehensive metabolomic profiling and pathways of the large biological data sets. Among the regulated pathways, 38 biomarkers were identified and two unique metabolic pathways were indicated to be differentially affected in HCV animals. The results provided a systematic view of the development and progression of HCV, and also could be u...Continue Reading

References

Jan 10, 2009·World Journal of Gastroenterology : WJG·Zhan-Fei TianXi-Ping Zhao
Nov 15, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xijun WangHui Sun
Dec 25, 2012·Molecular & Cellular Proteomics : MCP·Hui SunXijun Wang

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Citations

Apr 19, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Sha LiYibin Feng

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