Metabolomics approach of infant formula for the evaluation of contamination and degradation using hydrophilic interaction liquid chromatography coupled with mass spectrometry

Food Chemistry
Koichi InoueToshimasa Toyo'oka

Abstract

In this study including the field of metabolomics approach for food, the evaluation of untargeted compounds using HILIC-ESI/TOF/MS and multivariate statistical analysis method is proposed for the assessment of classification, contamination and degradation of infant formula. HILIC mode is used to monitor more detected numbers in infant formulas in the ESI-positive scan mode than the reversed phase. The repeatability of the non-targeted contents from 4 kinds of infant formulas based on PCA was less than the relative standard deviation of 15% in all groups. The PCA pattern showed that significant differences in the classification of types and origins, the contamination of melamine and the degradations for one week were evaluated using HILIC-ESI/TOF/MS. In the S-plot from the degradation test, we could identify two markers by comparison to standards as nicotinic acid and nicotinamide. With this strategy, the differences from the untargeted compounds could be utilized for quality and safety assessment of infant formula.

References

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Citations

Nov 28, 2015·International Journal of Molecular Sciences·Melinda M ThomasPhilip N Baker
Dec 23, 2015·Journal of the Science of Food and Agriculture·Koichi InoueToshimasa Toyo'oka
Sep 2, 2016·Biological & Pharmaceutical Bulletin·Toshimasa Toyo'oka
Apr 17, 2018·Electrophoresis·Tamara MartinovićDjuro Josić
May 13, 2017·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Toshimasa Toyo'oka
Jun 1, 2018·Journal of Analytical Methods in Chemistry·Federica BianchiMaria Careri
Jun 17, 2019·Current Nutrition Reports·Mimi PhanAlexis C Wood
Sep 29, 2021·Analytical Methods : Advancing Methods and Applications·Weifeng XueYingqian Chu

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