Metabolomics approach to investigate the ergogenic effect of Morinda citrifolia L. leaf extract on obese Sprague Dawley rats

Phytochemical Analysis : PCA
Nordiana Abdul MajidAhmad Haniff Jaafar

Abstract

Natural products are obtaining much acceptance as ergogenic aid, not only among athletes but also among the general population including people with excess body fat. Under normal circumstances, an obese person will have the desire and ability to exercise reduced; mainly because they are easily fatigued. Thus, they need to boost their energy production so that they can be more active and healthier. In this present work, Morinda citrifolia L. leaf extract (MLE) which is believed to possess ergogenic property, was evaluated on its effect on an obese animal model using 1 H-NMR based metabolomics. Rats were fed with high fat diet (HFD) for 12 weeks for obese development. Once this was achieved, all the rats underwent endurance exercise (forced swimming test) every 2 weeks for 8 weeks together with treatment. The time to exhaustion was recorded for each rat. Three different dosages of MLE: 50 mg/kg, 100 mg/kg and 200 mg/kg of body weight were used together with two positive controls: 5 mg/kg caffeine and 100 mg/kg green tea. Blood was collected before and after treatments for metabolomics study. Findings showed that feeding the rats at a dose of 200 mg/kg body weight MLE significantly prolonged the exhaustive swimming time of the rat...Continue Reading

References

Jun 1, 1988·The American Journal of Medicine·D E Salazar, G B Corcoran
Jan 1, 1986·Annual Review of Nutrition·C J Rebouche, D J Paulson
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·C MarconiP Cerretelli
Apr 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J O Holloszy, E F Coyle
Feb 1, 1994·Diabetologia·E A MullokandovM Brownlee
Nov 1, 1994·Acta Physiologica Scandinavica·P D BalsomB Sjödin
Jan 1, 1994·The Journal of Clinical Investigation·P A JanssonP Lönnroth
Mar 1, 1997·Medicine and Science in Sports and Exercise·K LimM Suzuki
Sep 15, 1999·Ophthalmology·C J DiaperG N Dutton
Mar 4, 2000·Sports Medicine·M S Bahrke, W R Morgan
Jan 11, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·S R Kimball, L S Jefferson
Feb 15, 2001·The Journal of the American Academy of Orthopaedic Surgeons·M D Silver
Sep 10, 2003·Current Sports Medicine Reports·David C Nieman
Jun 9, 2004·Journal of Ethnopharmacology·Kyungah JungDaeseok Han
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A RobergsDaryl Parker
Aug 24, 2004·The American Journal of Clinical Nutrition·Stuart A S Craig
Nov 26, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takatoshi MuraseIchiro Tokimitsu
Jul 23, 2005·Journal of Applied Physiology·Soh IwashitaPaul J Flakoll
Oct 15, 2005·Journal of Hepatology·Natalie J SerkovaClaus U Niemann
Jan 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takatoshi MuraseTadashi Hase
Dec 7, 2007·The Journal of Pharmacy and Pharmacology·Alison D Pawlus, Douglas A Kinghorn
May 27, 2008·Journal of the International Society of Sports Nutrition·Melvin H Williams
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·B Shivananda NayakAnderson Maxwell
Mar 21, 2009·Amino Acids·Guoyao Wu
Oct 3, 2009·Metabolism: Clinical and Experimental·Fabien PillardLaurent Brondel
Mar 30, 2010·Clinical Biochemistry·Michael Lever, Sandy Slow
Sep 4, 2010·Journal of Natural Medicines·Tomoko AkaseMasaki Aburada
Aug 23, 2011·The Journal of Physiological Sciences : JPS·Narattaphol CharoenphandhuJantarima Charoenphandhu
Jun 6, 2012·Journal of Biomedicine & Biotechnology·Baogang XieHorst Joachim Schirra
Jul 26, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chi-Chang HuangChia-Chung Hou
Sep 15, 2012·The Journal of Nutritional Biochemistry·Adrian B HodgsonDoris M Jacobs
Jan 1, 2013·Journal of Magnetic Resonance·Elena VinogradovRobert E Lenkinski
Jan 12, 2013·Applied Biochemistry and Biotechnology·Jingjing XuZhong Chen
Apr 23, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruei-Er WuChi-Chang Huang
May 30, 2013·Journal of Ginseng Research·Sergiy Oliynyk, Seikwan Oh
Nov 22, 2013·Molecular Nutrition & Food Research·Faisal AliSander Kersten
Apr 2, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yin LinKe Yuan
Sep 10, 2014·Molecular BioSystems·Zhen-Yu LiGuan-Hua Du
Dec 21, 2016·Applied Biochemistry and Biotechnology·Azliana Abu Bakar SajakFaridah Abas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.