Metabolomics as a clinical testing method for the diagnosis of vaginal dysbiosis

American Journal of Reproductive Immunology : AJRI
Emiley Watson, Gregor Reid

Abstract

Microbes play an important role in vaginal health, with lactobacilli a particularly abundant species. When dysbiosis occurs, the tools to determine whether it is a condition such as bacterial vaginosis, and whether it warrants antibiotic treatment, are currently suboptimal. We propose that standardization and implementation of an affordable metabolomics-based diagnostic technique could reduce instances of false positives, stress associated with misdiagnosis, and potentially save time and money. Basing diagnosis on the detection of pH elevated above 4.5 and specific polyamines could provide a better method to assist a physician determine whether treatment is warranted.

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Citations

Feb 5, 2019·The Journal of Infectious Diseases·Tara M Randis, Adam J Ratner
May 31, 2019·Journal of the International AIDS Society·Salim S Abdool KarimBrent L Williams
Oct 3, 2019·Scientific Reports·Camilla CeccaraniAntonella Marangoni
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Mathys J RedelinghuysMarleen M Kock
Jan 12, 2021·Frontiers in Cellular and Infection Microbiology·Huanrong LiFengxia Xue
May 25, 2021·The Journal of Pain : Official Journal of the American Pain Society·Jennifer S LabusAndrea Rapkin
Aug 8, 2021·International Journal of Molecular Sciences·AbuZar AnsariYoungju Kim

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