Metabolomics Biomarkers of Prostate Cancer: A Systematic Review

Diagnostics
Marouane KdadraEric Schiffer

Abstract

Prostate cancer (PCa) diagnosis with current biomarkers is difficult and often results in unnecessary invasive procedures as well as over-diagnosis and over-treatment, highlighting the need for novel biomarkers. The aim of this review is to provide a summary of available metabolomics PCa biomarkers, particularly for clinically significant disease. A systematic search was conducted on PubMed for publications from July 2008 to July 2018 in accordance with PRISMA guidelines to report biomarkers with respect to their application in PCa diagnosis, progression, aggressiveness, recurrence, and treatment response. The vast majority of studies report biomarkers with the ability to distinguish malignant from benign prostate tissue with a few studies investigating biomarkers associated with disease progression, treatment response or tumour recurrence. In general, these studies report high dimensional datasets and the number of analysed metabolites often significantly exceeded the number of available samples. Hence, observed multivariate differences between case and control samples in the datasets might potentially also be associated with pre-analytical, technical, statistical and confounding factors. Giving the technical and methodologica...Continue Reading

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Citations

Sep 9, 2020·Metabolomics : Official Journal of the Metabolomic Society·Noriko NakamuraRichard D Beger
Oct 27, 2020·The British Journal of Psychiatry : the Journal of Mental Science·Daniel Brennan
Jul 28, 2020·Urologic Oncology·Jennifer A StockertAshutosh K Tewari
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Aug 31, 2021·Journal of Pharmaceutical and Biomedical Analysis·Deepak KumarSatya Narain Sankhwar

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Methods Mentioned

BETA
biopsy
metabolomic profiling
blood collection
metabolomics profiling
NMR
biopsies
urine collection
metabolomic
PCA

Software Mentioned

PLS
OPLS
MaxEnt
MSTUS
DA

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