Metabolomics for the Effect of Biotin and Nicotinamide on Transition Dairy Cows

Journal of Agricultural and Food Chemistry
Xiaoshi WeiJunhu Yao

Abstract

The objective of this study was to evaluate alterations in serum metabolites of transition dairy cows affected by biotin (BIO) and nicotinamide (NAM) supplementation. A total of 40 multiparous Holsteins were paired and assigned randomly within a block to one of the following four treatments: control (T0), 30 mg/day BIO (TB), 45 g/day NAM (TN), and 30 mg/day BIO + 45 g/day NAM (TB+N). Supplemental BIO and NAM were drenched on cows from 14 days before the expected calving date. Gas chromatography time-of-flight/mass spectrometry was used to analyze serum samples collected from eight cows in every groups at 14 days after calving. In comparison to T0, TB, TN, and TB+N had higher serum glucose concentrations, while non-esterified fatty acid in TN and TB+N and triglyceride in TB+N were lower. Adenosine 5'-triphosphate was significantly increased in TB+N. Both TN and TB+N had higher glutathione and lower reactive oxygen species. Moreover, TB significantly increased inosine and guanosine concentrations, decreased β-alanine, etc. Certain fatty acid concentrations (including linoleic acid, oleic acid, etc.) were significantly decreased in both TN and TB+N. Some amino acid derivatives (spermidine in TN, putrescine and 4-hydroxyphenylethan...Continue Reading

References

Jan 1, 1988·Annual Review of Nutrition·K Dakshinamurti, J Chauhan
Oct 1, 1964·The Biochemical Journal·K J Hill, J L Mangan
Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor
Oct 6, 2000·Reproductive Toxicology·G LiuC L Hughes
Jun 11, 2002·Annual Review of Nutrition·Robert J McMahon
May 28, 2003·Trends in Pharmacological Sciences·Kenneth Maiese, Zhao Zhong Chong
Mar 17, 2004·Trends in Pharmacological Sciences·György HaskóCsaba Szabó
Feb 25, 2005·The Veterinary Journal·C CastilloJ L Benedito
Mar 16, 2006·Journal of Dairy Science·J K DrackleyC K Reynolds
May 23, 2006·Pharmaceutical Research·John C LindonJeremy K Nicholson
Dec 13, 2006·Trends in Biochemical Sciences·Peter BelenkyCharles Brenner
Mar 18, 2008·The Veterinary Journal·F J Mulligan, M L Doherty
Aug 16, 2008·The British Journal of Nutrition·Inka-Donata NiehoffPeter Lebzien
Nov 26, 2008·Veterinary Immunology and Immunopathology·Lorraine M Sordillo, Stacey L Aitken
Sep 29, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenneth MaieseYan Chen Shang
Dec 21, 2010·IUBMB Life·Jörg R AschenbachGregory B Penner
Jun 28, 2011·Journal of Dairy Science·B ChenJ X Liu
Sep 29, 2011·Journal of Dairy Science·S D MoreyB J Bradford
Oct 19, 2011·The International Journal of Biochemistry & Cell Biology·Sarawut Jitrapakdee
Dec 14, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hongmei YuanLi Zhang
Jul 5, 2013·Animal : an International Journal of Animal Bioscience·M Larsen, N B Kristensen
Jan 20, 2015·Journal of Proteome Research·Hui-Zeng SunJian-Xin Liu
Apr 22, 2015·Nucleic Acids Research·Jianguo XiaDavid S Wishart
Apr 25, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H-H ChenP-H Kuo
Jul 27, 2015·Journal of Dairy Science·B J BradfordA J Carpenter
Oct 18, 2015·Nucleic Acids Research·Minoru KanehisaMao Tanabe
Mar 8, 2018·Cell Metabolism·Sarah J MitchellRafael de Cabo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.