Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids

Cancer & Metabolism
Caroline H JohnsonGary Siuzdak

Abstract

Cancer cells that enter the metastatic cascade require traits that allow them to survive within the circulation and colonize distant organ sites. As disseminating cancer cells adapt to their changing microenvironments, they also modify their metabolism and metabolite production. A mouse xenograft model of spontaneous tumor metastasis was used to determine the metabolic rewiring that occurs between primary cancers and their metastases. An "autonomous" mass spectrometry-based untargeted metabolomic workflow with integrative metabolic pathway analysis revealed a number of differentially regulated metabolites in primary mammary fat pad (MFP) tumors compared to microdissected paired lung metastases. The study was further extended to analyze metabolites in paired normal tissues which determined the potential influence of metabolites from the microenvironment. Metabolomic analysis revealed that multiple metabolites were increased in metastases, including cholesterol sulfate and phospholipids (phosphatidylglycerols and phosphatidylethanolamine). Metabolite analysis of normal lung tissue in the mouse model also revealed increased levels of these metabolites compared to tissues from normal MFP and primary MFP tumors, indicating potential...Continue Reading

References

Apr 25, 2001·Circulation·M MertenP Thiagarajan
May 6, 2003·Journal of Lipid Research·Charles A Strott, Yuko Higashi
Oct 3, 2003·Journal of Cellular Biochemistry·Ellen AckerstaffZaver M Bhujwalla
Jun 25, 2009·Cancer Research·Ann F Chambers
Jan 19, 2011·The Journal of Experimental Medicine·Amparo WolfAbhijit Guha
Jan 25, 2011·Nature Reviews. Cancer·Rob A CairnsTak W Mak
Mar 30, 2011·PloS One·Markus RingnérJohan Staaf
Nov 1, 2011·Nature Medicine·Kristin M NiemanErnst Lengyel
Nov 22, 2011·Nature·Christian M MetalloGregory Stephanopoulos
Apr 27, 2012·Analytical Chemistry·Ralf TautenhahnGary Siuzdak
Sep 27, 2012·Cancer Discovery·Jason R Cantor, David M Sabatini
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jurre J KamphorstJoshua D Rabinowitz
Jul 19, 2013·PLoS Computational Biology·Shuzhao LiBali Pulendran
Dec 17, 2014·Analytical Chemistry·H Paul BentonGary Siuzdak
Jan 21, 2015·Cell·Jia Min LooSohail F Tavazoie
Mar 17, 2015·Nature Cell Biology·Lindsey K Boroughs, Ralph J DeBerardinis
Jun 30, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Liang HuChun-Fang Gao
Feb 5, 2016·Journal of Cellular Physiology·William B KinlawNancy B Kuemmerle
Mar 5, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wen ChenBaogen Zhan
Jun 28, 2016·Molecular Cancer Research : MCR·Renee E VickmanTimothy L Ratliff
Feb 12, 2017·Cell·Matthew G Vander Heiden, Ralph J DeBerardinis
Sep 1, 2015·Trends in Cancer·Anna C Obenauf, Joan Massagué

❮ Previous
Next ❯

Citations

Mar 13, 2019·International Journal of Cancer. Journal International Du Cancer·Juan J Arroyo-CrespoMaría J Vicent
May 31, 2021·Journal of Pharmaceutical and Biomedical Analysis·Nguyen Phuoc LongDong-Hyun Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
dissection

Software Mentioned

mummichog
XCMS Online
XCMS

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Related Papers

Chemistry & Biology
Julijana IvanisevicGary Siuzdak
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Heather Ann BrauerMelissa A Troester
© 2022 Meta ULC. All rights reserved