Metabolomics in Radiation-Induced Biological Dosimetry: A Mini-Review and a Polyamine Study

Biomolecules
Changhyun Roh

Abstract

In this study, we elucidate that polyamine metabolite is a powerful biomarker to study post-radiation changes. Metabolomics in radiation biodosimetry, the application of a metabolomics analysis to the field of radiobiology, promises to increase the understanding of biological responses by ionizing radiation (IR). Radiation exposure triggers a complex network of molecular and cellular responses that impacts metabolic processes and alters the levels of metabolites. Such metabolites have potential as biomarkers for radiation dosimetry. Among metabolites, polyamine is one of many potential biomarkers to estimate radiation response. In addition, this review provides an opportunity for the understanding of a radiation metabolomics in biodosimetry and a polyamine case study.

References

Dec 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S L HowellsJ R Griffiths
Aug 1, 1991·Annals of Medicine·J JänneP Leinonen
Aug 1, 1986·Agents and Actions·A M KafyD A Lewis
Jan 1, 1981·Differentiation; Research in Biological Diversity·O Heby
Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K L BeharJ W Prichard
Aug 1, 1996·The International Journal of Biochemistry & Cell Biology·N SeilerJ P Moulinoux
Sep 23, 1998·Trends in Biotechnology·S G OliverF Baganz
Apr 6, 2001·Cellular and Molecular Life Sciences : CMLS·T Thomas, T J Thomas
Mar 19, 2003·Critical Reviews in Biochemistry and Molecular Biology·Miguel Angel MedinaFrancisca Sánchez-Jiménez
Mar 26, 2003·Biochemical Society Transactions·H M Wallace
Sep 19, 2003·The Biochemical Journal·Heather M WallaceAlun Hughes
Oct 29, 2004·Nature Reviews. Cancer·Eugene W Gerner, Frank L Meyskens
Dec 21, 2004·Radiation Research·Terry C PellmarUNKNOWN Radiological/Nuclear Threat Countermeasures Working Group
Apr 15, 2005·Redox Report : Communications in Free Radical Research·François GaboriauJean-Guy Delcros
Dec 21, 2005·Journal of Cellular and Molecular Medicine·Miguel Angel MedinaFrancisca Sánchez-Jiménez
Apr 28, 2007·Nature Reviews. Drug Discovery·Robert A Casero, Laurence J Marton
Jan 15, 2008·Radiation and Environmental Biophysics·Otilia Nuta, Firouz Darroudi
Feb 12, 2009·International Journal of Radiation Biology·Peter O'Neill, Peter Wardman
Aug 3, 2010·International Journal of Radiation Biology·Badri N PandeyKaushala P Mishra
Oct 19, 2010·Archives of Toxicology·Mamas MamasRoyston Goodacre
Jun 23, 2011·International Journal of Radiation Biology·Stephen L CoyAlbert Fornace
Dec 27, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Changhyun RohSung Kee Jo
Oct 22, 2013·Radiation and Environmental Biophysics·Michael OrthClaus Belka
Nov 17, 2015·Expert Review of Molecular Diagnostics·Vijay K SinghHarvey B Pollard
Feb 13, 2016·Frontiers in Oncology·Smrithi S MenonAnatoly Dritschilo

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Citations

Aug 17, 2020·Metabolites·Merriline M SatyamitraAndrea L DiCarlo
Nov 9, 2019·Dose-response : a Publication of International Hormesis Society·Yiying GaoJianping Cao
Jul 4, 2020·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hanxu WuChang Wang

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
PCA

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