Metabolomics of Major Depressive Disorder and Bipolar Disorder: Overview and Future Perspective

Advances in Clinical Chemistry
Kenji Hashimoto

Abstract

Major depressive disorder (MDD) and bipolar disorder (BD) are the most common mood disorders. They are etiologically related, but clinically distinct psychiatric illnesses. Their shared clinical features result in high rates of misdiagnosis due to a lack of biomarkers that allow their differentiation. BD is more frequently misdiagnosed as MDD because of overlapping symptomology, often later onset of mania, and frequent occurrence of depressive episodes in patients with BD. Misdiagnosis is also increased when patients with BD present symptoms indicative of a clinically significant depressive episode, but are premorbid for manic symptoms, or previous manic states not recognized. Therefore, the development of specific biomarkers for these disorders would be invaluable for establishing the correct diagnosis and treatment of MDD and BD. This chapter presents an overview and future perspective of the identification of biomarkers for mood disorders using metabolomics.

Citations

Apr 28, 2018·Expert Review of Molecular Diagnostics·Cristina MoraAnnamaria Cattaneo
Oct 2, 2019·Frontiers in Neuroscience·Sudeepa BhattacharyyaRima Kaddurah-Daouk
Dec 12, 2020·Psychiatry Research·Paulo J C SuenAndre R Brunoni
Mar 31, 2021·ESC Heart Failure·Angela S Koh, Jean-Paul Kovalik
Oct 18, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gordana Nedic ErjavecNela Pivac
Aug 21, 2021·Frontiers in Psychiatry·Lining DuanYousheng Mo

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