Metabolomics profiling reveals novel markers for leukocyte telomere length

Aging
Jonas ZiererCristina Menni

Abstract

Leukocyte telomere length (LTL) is considered one of the most predictive markers of biological aging. The aim of this study was to identify novel pathways regulating LTL using a metabolomics approach. To this end, we tested associations between 280 blood metabolites and LTL in 3511 females from TwinsUK and replicated our results in the KORA cohort. We furthermore tested significant metabolites for associations with several aging-related phenotypes, gene expression markers and epigenetic markers to investigate potential underlying pathways. Five metabolites were associated with LTL: Two lysolipids, 1-stearoylglycerophosphoinositol (P=1.6×10(-5)) and 1-palmitoylglycerophosphoinositol (P=1.6×10(-5)), were found to be negatively associated with LTL and positively associated with phospholipase A2 expression levels suggesting an involvement of fatty acid metabolism and particularly membrane composition in biological aging. Moreover, two gamma-glutamyl amino acids, gamma-glutamyltyrosine (P=2.5×10(-6)) and gamma-glutamylphenylalanine (P=1.7×10(-5)), were negatively correlated with LTL. Both are products of the glutathione cycle and markers for increased oxidative stress. Metabolites were also correlated with functional measures of agi...Continue Reading

References

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Citations

Aug 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Stephanie Venn-WatsonNicholas J Schork
Jul 26, 2018·Nature Reviews. Cardiology·Anna PiccaChristiaan Leeuwenburgh
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sonja EntringerPathik D Wadhwa
Jan 28, 2020·Nutrition and Healthy Aging·Arjun Sengupta, Aalim M Weljie
May 22, 2020·Journal of Proteome Research·Liwei ChenPatricia L Conway
Nov 3, 2021·The Plant Journal : for Cell and Molecular Biology·Damini JaiswalPramod P Wangikar

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Methods Mentioned

BETA
chip
metabolomics profiling

Software Mentioned

lme4
R package meta
R package pwr
R

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