Metabolomics reveals novel biomarkers of illegal 5-nitromimidazole treatment in pigs. Further evidence of drug toxicity uncovered

Food Chemistry
M AriasC T Elliott

Abstract

The aim of the study was to investigate the potential of a metabolomics platform to distinguish between pigs treated with ronidazole, dimetridazole and metronidazole and non-medicated animals (controls), at two withdrawal periods (day 0 and 5). Livers from each animal were biochemically profiled using UHPLC-QTof-MS in ESI+ mode of acquisition. Several Orthogonal Partial Least Squares-Discriminant Analysis models were generated from the acquired mass spectrometry data. The models classified the two groups control and treated animals. A total of 42 ions of interest explained the variation in ESI+. It was possible to find the identity of 3 of the ions and to positively classify 4 of the ionic features, which can be used as potential biomarkers of illicit 5-nitroimidazole abuse. Further evidence of the toxic mechanisms of 5-nitroimidazole drugs has been revealed, which may be of substantial importance as metronidazole is widely used in human medicine.

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Citations

Jan 25, 2018·Animal : an International Journal of Animal Bioscience·Y T ZhangX D Liao
Nov 15, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Patrick J Quinlivan, Rita K Upmacis
Mar 16, 2021·Journal of Veterinary Pharmacology and Therapeutics·Sol M Rivera-VelezNicolas F Villarino
Mar 20, 2021·Analytica Chimica Acta·M Hernández-MesaG Dervilly
May 28, 2021·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Gaël TouchaisEstelle Dubreil
Aug 20, 2021·Ecotoxicology and Environmental Safety·Li ZhuYu Zhang
Sep 20, 2019·Journal of Agricultural and Food Chemistry·Qianqian WangZhi Wang

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