Metabolomics study of fatigue in patients with rheumatoid arthritis naïve to biological treatment

Rheumatology International
Izabella SurowiecRoald Omdal

Abstract

Fatigue occurs in all chronic inflammatory diseases, in cancer, and in some neurological conditions. Patients often regard fatigue as one of their most debilitating problems, but currently there is no established treatment and the mechanisms that lead to and regulate fatigue are incompletely understood. Our objective was to more completely understand the physiology of this phenomenon. Twenty-four patients with rheumatoid arthritis (RA) naïve to treatment with biological drugs were enrolled for the study. Fatigue was measured with a fatigue visual analogue scale (fVAS). Ethylenediaminetetraacetic acid (EDTA) plasma samples were subjected to gas chromatography-time-of-flight mass spectrometry (GC/MS-TOF)-based metabolite profiling. Obtained metabolite data were evaluated by multivariate data analysis with orthogonal projections to latent structures (OPLS) method to pinpoint metabolic changes related to fatigue severity. A significant multivariate OPLS model was obtained between the fVAS scores and the measured metabolic levels. Increasing fatigue scores were associated with a metabolic pattern characterized by down-regulation of metabolites from the urea cycle, fatty acids, tocopherols, aromatic amino acids, and hypoxanthine. Uri...Continue Reading

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Citations

Jun 17, 2016·Scandinavian Journal of Gastroenterology·Tore GrimstadRoald Omdal
Apr 1, 2017·Nature Reviews. Rheumatology·Cornelia M Weyand, Jörg J Goronzy
Apr 8, 2017·Current Rheumatology Reports·Patricia Katz
Feb 17, 2017·Current Opinion in Rheumatology·Patricia Katz
Feb 10, 2017·The British Journal of Dermatology·I M SkoieR Omdal
Aug 28, 2018·International Journal of Rheumatic Diseases·Latika GuptaRamnath Misra
Feb 28, 2021·Journal of Pharmaceutical and Biomedical Analysis·Ilona DudkaAndrzej Szuba
Jul 25, 2021·International Journal of Molecular Sciences·Katarzyna Bogunia-KubikPiotr Młynarz

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