Metabolomics study of hematopoietic function of Angelica sinensis on blood deficiency mice model

Journal of Ethnopharmacology
Peng-Ling LiYan-Ming Wei

Abstract

Angelica sinensis (AS) has been used in traditional Chinese medicine for thousands of years to enrich and invigorate blood. In this study, the aim is to investigate the influence of AS on metabolism of blood deficiency mice model and to explore its anti-blood deficiency mechanism. The blood deficiency mice model was induced by being hypodermically injected with N-acetyl phenylhydrazine (APH) and being intraperitoneally injected with cyclophosphamide (CTX). Gas chromatography-mass spectrometry (GC-MS), principle component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were used to identify potential biomarkers in plasma and splenic tissue. The levels of white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB) and platelet (PLT) showed a trend to return to control group after administrating with AS, while the dose of 10g/kg showed the best effect. Potential metabolite biomarkers (nine in the plasma and nine in the spleen homogenates) were identified in this study. These biomarkers were mainly related to five metabolic pathways, such as arachidonic acid metabolism, valine, leucine and isoleucine biosynthesis, glycine, serine and threonine metabolism, arginine and proline metabolism and TCA cycle. Met...Continue Reading

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Citations

Feb 24, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shao LiuHai-Tao Liu
Dec 15, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jian ShiChang-Xiao Liu
May 12, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ningli WangDuolong Di
Aug 9, 2016·Journal of Ethnopharmacology·Chih-Wei ChangMei-Chich Hsu
Dec 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi-Xiao LiShang-Bin Li
Aug 24, 2018·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Carole Y FisherDavid W Sibbritt
Jul 1, 2018·Natural Products and Bioprospecting·Qi ZhaoFei Li
Oct 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kaixue ZhangZhigang Yang
Jun 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huiying LiuYuan Qu
Sep 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nopmullee TanhuadKanit Bhukhai

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