Abstract
Angelica sinensis (AS) has been used in traditional Chinese medicine for thousands of years to enrich and invigorate blood. In this study, the aim is to investigate the influence of AS on metabolism of blood deficiency mice model and to explore its anti-blood deficiency mechanism. The blood deficiency mice model was induced by being hypodermically injected with N-acetyl phenylhydrazine (APH) and being intraperitoneally injected with cyclophosphamide (CTX). Gas chromatography-mass spectrometry (GC-MS), principle component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were used to identify potential biomarkers in plasma and splenic tissue. The levels of white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB) and platelet (PLT) showed a trend to return to control group after administrating with AS, while the dose of 10g/kg showed the best effect. Potential metabolite biomarkers (nine in the plasma and nine in the spleen homogenates) were identified in this study. These biomarkers were mainly related to five metabolic pathways, such as arachidonic acid metabolism, valine, leucine and isoleucine biosynthesis, glycine, serine and threonine metabolism, arginine and proline metabolism and TCA cycle. Met...Continue Reading
References
Nov 1, 1993·Japanese Journal of Pharmacology·S KobayashiM Kimura
May 18, 2000·Phytotherapy Research : PTR·T K YimK M Ko
May 23, 2001·Journal of Agricultural and Food Chemistry·J LiuJ L Bolton
Apr 26, 2006·Journal of the American Academy of Dermatology·Leonid Benjamin TrostEllen Calogeras
Apr 4, 2007·The British Journal of Nutrition·Peng LiGuoyao Wu
Jun 2, 2007·Journal of Proteome Research·Ke YuLanjuan Li
Oct 25, 2007·Biochemical Society Transactions·P NewsholmeL Brennan
Aug 19, 2008·The Analyst·Peng GaoGuowang Xu
Mar 30, 2010·Experimental Hematology·Pei-Jou LiuBeen-Huang Chiang
Nov 13, 2010·European Neurology·Xiao-Ping WangMaurice Preter
Feb 8, 2011·Journal of Chromatography. a·Qun GuPat Sandra
Apr 5, 2011·International Immunopharmacology·Yu-Wen SuYing-Chieh Tsai
May 14, 2011·Neuro-oncology·Horng-Jyh HarnTzyy-Wen Chiou
Jul 28, 2011·Electrophoresis·Edgar P MoraesCoral Barbas
Oct 29, 2011·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Weixia LiJin'ao Duan
Jul 31, 2012·Journal of Chromatography. a·Zhanying HongLiming Zhang
Apr 2, 2013·Journal of Ethnopharmacology·Yamei CaiYifeng Chai
Oct 25, 2013·The American Journal of Clinical Nutrition·Yuvaraj MahendranMarkku Laakso
Jan 1, 2014·Journal of Ethnopharmacology·Yongli HuaPeng Ji
Mar 4, 2014·Journal of Ethnopharmacology·Xuqin ShiJin-ao Duan
May 6, 2014·Journal of Chromatography. a·Weixia LiJin-ao Duan
May 20, 2014·Journal of Ethnopharmacology·Hong ZhangYe Li
Citations
Feb 24, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shao LiuHai-Tao Liu
Dec 15, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jian ShiChang-Xiao Liu
Nov 19, 2015·International Immunopharmacology·Wanling YaoYanming Wei
May 12, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ningli WangDuolong Di
May 18, 2016·Journal of Ethnopharmacology·Xin ChangXian-Sheng Meng
Aug 9, 2016·Journal of Ethnopharmacology·Chih-Wei ChangMei-Chich Hsu
Dec 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi-Xiao LiShang-Bin Li
Aug 24, 2018·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Carole Y FisherDavid W Sibbritt
Jun 18, 2019·Biomedical Chromatography : BMC·Yao HeChaomei Fu
Jul 1, 2018·Natural Products and Bioprospecting·Qi ZhaoFei Li
Oct 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kaixue ZhangZhigang Yang
Feb 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee
Feb 11, 2020·Frontiers in Pharmacology·Zejun ZhangYin Xiong
Jun 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huiying LiuYuan Qu
Mar 22, 2019·Frontiers in Pharmacology·Wenxia GongXuemei Qin
Aug 10, 2019·Bioorganic & Medicinal Chemistry·Xiaoman ZhengYan Zhao
Nov 24, 2020·Pharmaceutical Biology·Peng JiYanqiao Wen
Apr 25, 2021·Chemistry & Biodiversity·Yan ZhaoAnjun Liu
Jul 21, 2021·BMC Veterinary Research·Mengyue TianYuzhong Ma
Aug 1, 2020·Journal of Ethnopharmacology·Qing DuShui-Han Zhang
Sep 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nopmullee TanhuadKanit Bhukhai