Metabonomic biomarkers for risk factors of chronic kidney disease

International Urology and Nephrology
Libing Ye, Wei Mao

Abstract

Chronic kidney disease, characterized by gradual loss of renal function and irreversible progression, is becoming a major public health problem worldwide. Chronic kidney disease may lead to end-stage renal disease, as well as increase the morbidity and mortality associated with cardiovascular disease. This review focuses on identifying risk factors indicating the need for intervention in early stages of chronic kidney disease, as well as determining factors that may improve patient prognosis. However, all the risk factors giving rise to the progression of chronic kidney disease have not yet been identified. Metabonomics is a new type of omics that reflects the real-time pathophysiology of disease and focuses on endogenous metabolites of low molecular weight. This new and powerful tool has recently been used to explore metabonomic biomarkers of chronic kidney disease, enabling early diagnosis and timely intervention and treatment to slow the progression of chronic kidney disease. This review summarizes recent findings on the identification, using a metabonomic approach, of biomarkers associated with risk factors for the development and progression of chronic kidney disease.

References

Jun 29, 2002·Journal of the American Academy of Nurse Practitioners·Mary Jo Goolsby
May 23, 2006·Pharmaceutical Research·John C LindonJeremy K Nicholson
Sep 9, 2008·Cell·Elaine HolmesJeremy K Nicholson
Oct 25, 2008·Nature·Jeremy K Nicholson, John C Lindon
Feb 10, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Allan J CollinsLawrence Agodoa
Jul 9, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takafumi ToyoharaTakaaki Abe
Oct 14, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Luigi AtzoriVassilios Fanos
Oct 26, 2011·Nature Reviews. Nephrology·Robert H Weiss, Kyoungmi Kim
Nov 2, 2011·Molecular BioSystems·Bin ZhouHabtom W Ressom
Aug 24, 2012·Current Opinion in Nephrology and Hypertension·Sacha A De SerresAdeera Levin
Dec 12, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Vallabh O ShahDavid L Vander Jagt
Jan 4, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Allan J CollinsLawrence Agodoa
Mar 30, 2013·Organogenesis·Hiromi I Wettersten, Robert H Weiss
Apr 11, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ying-Yong Zhao
May 21, 2013·Journal of the American Society of Nephrology : JASN·Eugene P RheeRobert E Gerszten
Jun 4, 2013·Lancet·Vivekanand JhaChih-Wei Yang
Sep 21, 2013·Kidney International·Maria Posada-AyalaGloria Alvarez-Llamas
Nov 16, 2013·Analytical and Bioanalytical Chemistry·Toshihiro KobayashiMasahiro Kohno
Dec 25, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dorothee AtzlerTanja Zeller
Feb 18, 2014·Biochemical and Biophysical Research Communications·Toshihiro KobayashiNoriaki Tanaka
Jun 26, 2014·Seminars in Dialysis·Moshe ShasharVipul Chitalia
Jul 12, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Bing YuEric Boerwinkle
Jul 16, 2014·Kidney International Supplements·Rumeyza Kazancioğlu

❮ Previous
Next ❯

Citations

Jul 12, 2018·American Journal of Physiology. Renal Physiology·Tafadzwa ChihangaMichael A Kennedy
Jan 12, 2021·Metabolomics : Official Journal of the Metabolomic Society·Yuko YamaguchiRichard D Semba
Dec 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hongdie CaiXin Peng
Feb 1, 2021·Medical Image Analysis·Israa AlnazerChristine Fernandez-Maloigne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.