Metabotropic Ca(2+) channel-induced Ca(2+) release and ATP-dependent facilitation of arterial myocyte contraction

Proceedings of the National Academy of Sciences of the United States of America
Alberto Del Valle-RodríguezJuan Ureña

Abstract

Voltage-gated Ca(2+) channels in arterial myocytes can mediate Ca(2+) release from the sarcoplasmic reticulum and, thus, induce contraction without the need of extracellular Ca(2+) influx. This metabotropic action of Ca(2+) channels (denoted as calcium-channel-induced calcium release or CCICR) involves activation of G proteins and the phospholipase C-inositol 1,4,5-trisphosphate pathway. Here, we show a form of vascular tone regulation by extracellular ATP that depends on the modulation of CCICR. In isolated arterial myocytes, ATP produced facilitation of Ca(2+)-channel activation and, subsequently, a strong potentiation of CCICR. The facilitation of L-type channel still occurred after full blockade of purinergic receptors and inhibition of G proteins with GDPbetaS, thus suggesting that ATP directly interacts with Ca(2+) channels. The effects of ATP appear to be highly selective, because they were not mimicked by other nucleotides (ADP or UTP) or vasoactive agents, such as norepinephrine, acetylcholine, or endothelin-1. We have also shown that CCICR can trigger arterial cerebral vasoconstriction in the absence of extracellular calcium and that this phenomenon is greatly facilitated by extracellular ATP. Although, at low concent...Continue Reading

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Citations

Oct 30, 2007·Nature Neuroscience·Costantino Iadecola, Maiken Nedergaard
Feb 29, 2008·Cerebrovascular Diseases·Vikram D JadhavTony Jer-Fu Lee
Jun 7, 2014·Pharmacological Reports : PR·Khrystyna Yu SukhanovaDmitri V Gordienko
Jan 15, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Melike Hacer OzkanSerdar Uma
Aug 21, 2012·Trends in Cardiovascular Medicine·Juan Ureña, José López-Barneo
Sep 24, 2010·Kidney International·Roland S Wu, Steven O Marx
Jul 16, 2008·Trends in Pharmacological Sciences·Martyn P Mahaut-SmithIman S Gurung
Feb 18, 2010·Journal of the American Society of Hypertension : JASH·Brandi M WynneR Clinton Webb
Jun 30, 2018·American Journal of Physiology. Heart and Circulatory Physiology·William F Jackson, Erika M Boerman
Jan 21, 2010·Physiological Reviews·Susan Wray, Theodor Burdyga
Mar 17, 2010·European Journal of Cell Biology·Shipa R Ghosh, Ian A Hope

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