Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus

Epilepsy Research
F R TangE A Ling

Abstract

A comparative study of the expression of metabotropic glutamate receptor 2/3 (mGluR2/3) was done in the hippocampus of rats and mice after pilocarpine-induced status epilepticus (APISE), and of patients with mesial temporal lobe epilepsy. At 1 day APISE, there was a marked increase in mGluR2/3 immunoreactivity in the stratum lacunosum moleculare (SLM) of CA1 area and in the middle one-third of the molecular layer (MM) of the dentate gyrus. Immuno-electron microscopic study showed degenerating mGluR2/3 positive axons in the SLM of CA1 area at 1 day APISE. From 7 days, mGluR2/3 immunopositive product decreased, and by 31 days APISE, it almost disappeared in two-thirds of the SLM near CA2. In the mouse model at 2 months APISE, mGluR2/3 immunopositive product in two-thirds of the SLM near the stratum radiatum disappeared, and so did in the whole SLM of CA1 area in patients with mesial temporal lobe epilepsy. Neuropharmacological study by intravenous injection of mGluR2/3 agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate [(2R,4R)-APDC] at different doses at 1h during pilocarpine induced status epilepticus showed that (2R,4R)-APDC could not stop seizures and neuronal death in the hilus of the dentate gyrus. The present study, theref...Continue Reading

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Citations

Jul 1, 2008·Oxidative Medicine and Cellular Longevity·Kenneth MaieseJinling Hou
Dec 21, 2013·Biochemical Pharmacology·Tanja Babic, R Alberto Travagli
Oct 29, 2014·The European Journal of Neuroscience·W Saskia van der HelPierre N E de Graan
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Dec 30, 2014·Acta neurologica Belgica·Stefanie DedeurwaerdereThomas Steckler
Jul 16, 2010·Seizure : the Journal of the British Epilepsy Association·Jian Xin LiuFeng Ru Tang
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Apr 29, 2008·Neuron·Jonathon WetheringtonRay Dingledine
Jul 14, 2005·Neuropharmacology·Harlan E ShannonAnn E Kingston
Oct 6, 2020·Frontiers in Neurology·Allison R Peterson, Devin K Binder
Aug 28, 2019·Progress in Neurobiology·Ying YuJianxiong Jiang

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