Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Byong Chul YooJae-Gahb Park

Abstract

5-Fluorouracil (5-FU) has been the mainstay treatment for colorectal cancer for the past few decades. However, as with other cancers, development of 5-FU resistance has been a major obstacle in colorectal cancer chemotherapy. The purpose of this study was to gain further understanding of the mechanisms underlying 5-FU resistance in colorectal cancer cells. A 5-FU-resistant cell line was established from the human colon cancer cell line SNU-769A. Protein extracts from these two cell lines (parent and resistant) were analyzed using comparative proteomics to identify differentially expressed proteins. 5-FU-resistant human colon cancer cells were found to overexpress metabotropic glutamate receptor 4 (mGluR4). Other experiments showed cellular resistance to 5-FU (i.e., cell survival) was altered by the mGluR4 agonist l-2-amino-4-phosphonobutyric acid (L-AP 4), and by the mGluR4 antagonist (S)-amino-2-methyl-4-phosphonobutanoic acid (MAP 4), in that L-AP 4 increased 5-FU resistance in SNU-769A cells, whereas MAP 4 ablated 5-FU resistance in 5-FU-resistant cells. However, there was no significant effect of L-AP 4 or MAP 4 on basal cAMP and thymidylate synthase levels. Interestingly, 5-FU down-regulated mGluR4 expression, and MAP 4 su...Continue Reading

References

Jun 1, 1991·Anti-cancer Drugs·G H Blijham
Apr 28, 1995·Journal of Medicinal Chemistry·T KnöpfelH Allgeier
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A BeckG Milano
Aug 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Herrmann
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A F SobreroJ R Bertino
Sep 3, 1998·Journal of Neuroscience Research·K Borodezt, S R D'Mello
Nov 11, 1998·General Pharmacology·R M MaderG G Steger
May 7, 1999·Brain Research Bulletin·S S GillP F McGuire
Jun 11, 1999·International Journal of Cancer. Journal International Du Cancer·J H OhJ G Park
Apr 3, 2001·Trends in Pharmacological Sciences·T M Skerry, P G Genever
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·W RzeskiC Ikonomidou
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·E A Cavalheiro, J W Olney
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Qingchun TongAnnette L Kirchgessner
Jun 27, 2002·Biochimica Et Biophysica Acta·G J PetersH M Pinedo
Nov 8, 2002·British Medical Bulletin·Ian Chau, David Cunningham

❮ Previous
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Citations

Jun 16, 2009·Histochemistry and Cell Biology·Andrzej StepulakChrysanthy Ikonomidou
Jun 1, 2008·Biomarkers in Medicine·Judith Ymn Derijks-EngwegenJos H Beijnen
Feb 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ja-Lok Ku, Jae-Gahb Park
Mar 13, 2014·Journal of Neural Transmission·Andrzej StepulakChrysanthy Ikonomidou
Feb 21, 2016·Neuropharmacology·Lumeng J YuSuzie Chen
Oct 8, 2005·Expert Review of Proteomics·Anita R SkandarajahRichard J Simpson
Aug 26, 2010·Pharmaceuticals·Janet Wangari-TalbotSuzie Chen
Dec 23, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Laura TaddiaMaria Paola Costi
Sep 15, 2007·Cancer Treatment Reviews·Jian-Ting Zhang, Yang Liu
Aug 7, 2007·Neuropharmacology·Daniela MelchiorriFerdinando Nicoletti
Apr 17, 2007·Trends in Pharmacological Sciences·Ferdinando NicolettiDaniela Melchiorri
Aug 1, 2009·Proteomics. Clinical Applications·Hermann Lage
Jun 6, 2006·Cancer·Laura SmithUNKNOWN Cancer Biology Proteomics Group
Jun 5, 2012·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Jessica Teh, Suzie Chen
Oct 26, 2012·The Journal of Pathology·Andrew D BeggsIan P M Tomlinson
Nov 6, 2012·European Journal of Pharmacology·Marcela Julio-PieperJohn F Cryan
May 28, 2011·Biochimica Et Biophysica Acta·Mario MancinoVanessa Almendro
Nov 26, 2005·Expert Opinion on Investigational Drugs·Niki KalaritiMichael Koutsilieris
Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kanchan VishnoiAlok C Bharti
Jun 21, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Baocheng GongFunan Liu
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ning ZhangWei-Shan Chen
Oct 5, 2019·Bioscience, Biotechnology, and Biochemistry·Zengliang ZhangShuxun Hou
Jan 14, 2011·Pharmacological Reviews·Marcela Julio-PieperJohn F Cryan
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hee Jin ChangJae-Gahb Park
Dec 11, 2021·Science Advances·Zhuoya WanSong Li

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