PMID: 9555048May 16, 1998Paper

Metabotropic glutamate receptor agonist increases neuropeptide mRNA expression in rat striatum

Brain Research. Molecular Brain Research
J Q Wang, J F McGinty

Abstract

Metabotropic glutamate receptors (mGluR) are coupled to multiple intracellular second messenger systems through G-proteins and densely expressed by medium spiny projection neurons in the rat striatum. Unlike ionotropic glutamate receptors which mediate rapid synaptic transmission, mGluRs are important for relatively long-lasting modulation of neuronal metabotropic activity, possibly including gene expression, in response to cellular stimulation. In this study, the effects of acute injection of the selective mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on behavior and striatal neuropeptide mRNA expression were evaluated in chronically-cannulated rats. Unilateral injection of ACPD into the dorsal striatum at doses of 0.8, 4, 20, 100, 500 and 1000 nmol had no significant effect on spontaneous behavioral activity. However, intrastriatal ACPD (0.8, 4, 20 and 100 nmol) dose-dependently elevated preprodynorphin (PPD), substance P (SP) and preproenkephalin (PPE) mRNA expression in the dorsal striatum as revealed by quantitative in situ hybridization. PPD/SP mRNAs showed a biphasic response to a single injection of ACPD as the expression of these two mRNAs was increased at 3 and 6 h, decreased at 11 h, and retu...Continue Reading

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Citations

Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·F LiuP Greengard
Oct 30, 2010·Genes, Brain, and Behavior·A M DlugosH de Wit
Jul 23, 1999·Annals of the New York Academy of Sciences·J F McGinty
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Per SvenningssonPaul Greengard
Oct 7, 2004·Neuropharmacology·Angus C NairnPaul Greengard
Apr 1, 1999·Addiction Biology·J Q Wang, J F McGinty

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