Metabotropic glutamate receptor inhibition of visceral afferent potassium currents

Brain Research
M Hay, K A Lindsley

Abstract

The effects of metabotropic glutamate receptor activation (mGluR) on voltage-gated potassium currents have been characterized in visceral sensory afferent neurons. L-Glutamate is known to be a primary neurotransmitter in visceral afferents which terminate at the level of the nucleus of the solitary tract (NTS). Synaptic communication between these afferents and the NTS has been shown to involve both postsynaptic ionotropic and presynaptic metabotropic glutamate receptor activation. The purpose of the present study was to determine the effects of mGluR activation on voltage-gated potassium currents in visceral sensory neurons. Application of mGluR agonist t-ACPD inhibited both the peak and the steady state voltage-gated potassium current in 39 out of 56 visceral afferent neurons tested (70%) by 22.0 +/- 3 and 22.8 +/- 2%, respectively. Voltage and pharmacological protocols were utilized to isolate the potassium current affected by mGluR activation. Increasing the holding potential from -100 mV to -30 mV only partially attenuated the inhibitory effects of t-ACPD (decreased effect by 11%), suggesting that t-ACPD modulates both a voltage insensitive and a voltage-sensitive potassium current. In addition, 4-aminopyridine (5 microM) ...Continue Reading

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Citations

May 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anna W LeeDonald W Pfaff
Aug 7, 2009·Journal of Neurophysiology·Ping DengZao C Xu
Dec 15, 2010·Autonomic Neuroscience : Basic & Clinical·Kirsteen N Browning, R Alberto Travagli
Sep 2, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K N Browning, R A Travagli
Jun 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Qingchun Tong, Annette L Kirchgessner

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