Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect

Brain Sciences
Chelsea R KastenTiffany A Wills

Abstract

Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake. However, these conditions are often comorbid and might precipitate one another. Acute and protracted ethanol withdrawal can lead to negative affective states. In turn, these states are primary drivers of alcohol relapse, particularly among women. The current review synthesizes preclinical studies that have observed the role of mGlu5 receptor modulation in negative affective states following ethanol exposure. The primary behavioral assays discussed are ethanol-seeking and intake, development and extinction of ethanol-associated cues and contexts, behavioral despair, and anxiety-like activity. The work done to-date supports mGlu5 receptor modulation as a promising target for mediating negative affective states to reduce ethanol intake or prevent relapse. Limitations in interpreting these data include the lack of models that use alcohol-dependent animals, limited use of adolescent and female subjects, and a lack of comprehensive evaluations of negative affective-like behavior.

References

Jan 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pia BäckströmRainer Spanagel
Jul 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karen K SzumlinskiPeter W Kalivas
Sep 28, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Brian A McMillenHelen L Williams
Mar 15, 2006·Pharmacology, Biochemistry, and Behavior·J Nesic, T Duka
May 23, 2007·The International Journal of Neuropsychopharmacology·Cameron L AdamsAndrew J Lawrence
Jun 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen K SzumlinskiTod E Kippin
Dec 29, 2007·Alcoholism, Clinical and Experimental Research·Joyce BesheerClyde W Hodge
Apr 2, 2008·The International Journal of Neuropsychopharmacology·Yuri A Blednov, R Adron Harris
Apr 11, 2008·The International Journal of Neuropsychopharmacology·Michael K BirdAndrew J Lawrence
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brad A GrueterDanny G Winder
Jul 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Debra K CozzoliKaren K Szumlinski
Jul 28, 2009·Current Drug Abuse Reviews·M Foster Olive
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Mar 13, 2010·Current Opinion in Psychiatry·Kimberly Nixon, Justin A McClain
Apr 7, 2010·European Journal of Pharmacology·Agnes SimonyiGert R J Christoffersen
Aug 14, 2010·Cerebral Cortex·Darah E Fontanez-NuinJames T Porter
Dec 15, 2010·Alcoholism, Clinical and Experimental Research·Suzanne E ThomasDavid J Drobes
Mar 4, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Richard M Cleva, M Foster Olive
Apr 19, 2011·The American Journal of Psychiatry·Alexandra DeschwandenGregor Hasler
Apr 30, 2011·Neuroscience and Biobehavioral Reviews·Noa Albelda, Daphna Joel
May 17, 2011·Pharmacology, Biochemistry, and Behavior·Carlos Riaza Bermudo-SorianoEnrique Baca-Garcia
Feb 3, 2012·Pharmacology, Biochemistry, and Behavior·Courtney M SinclairJustin T Gass
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Debra K CozzoliKaren K Szumlinski
Jun 27, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A A HerroldT C Napier
Jul 4, 2012·Frontiers in Molecular Neuroscience·Marina E Wolf, Kuei Y Tseng

❮ Previous
Next ❯

Citations

Apr 9, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C R KastenT A Wills
Jul 23, 2021·The Journal of Clinical Investigation·Nathan D WintersSachin Patel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.