PMID: 9550154Apr 29, 1998Paper

Metabotropic glutamate receptor subtypes in axon terminals of projection fibers from the main and accessory olfactory bulbs: a light and electron microscopic immunohistochemical study in the rat

The Journal of Comparative Neurology
E WadaN Mizuno

Abstract

Localization of metabotropic glutamate receptor subtypes, mGluR1, mGluR1alpha, mGluR2/3, mGluR4a, mGluR5, mGluR7a, mGluR7b, and mGluR8, was examined in some of the target areas of projection fibers from the main and accessory olfactory bulbs (MOB and AOB) by using subtype-specific antibodies. The superficial layer of the olfactory tubercle and layer Ia of the piriform cortex, the target areas of MOB, showed marked mGluR1-, mGluR5-, mGluR7a-, and mGluR8-like immunoreactivities (-LI), and rather weak mGluR2/3-LI. The periamygdaloid cortical region including the target areas of both MOB and AOB showed intense mGluR2/3-LI as well as marked mGluR1-, mGluR5-, mGluR7a-, and mGluR8-LI. No significant mGluR1alpha-, mGluR4a-, or mGluR7b-LI was seen in these regions. After transection of the lateral olfactory tract, mGluR2/3-, mGluR7a-, and mGluR8-LI were reduced markedly in the target regions on the side ipsilateral to the transection; no significant changes were detected in mGluR1- or mGluR5-LI. Double labeling experiments indicated light and electron microscopically colocalization of mGluR7a- and mGluR8-LI in axon terminals on dendritic shafts of presumed interneurons in the superficial layer of the olfactory tubercle and layer Ia of t...Continue Reading

Citations

Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron R Best, Donald A Wilson
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron R BestDonald A Wilson
Sep 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert RendenHenrique von Gersdorff
Nov 10, 2006·Journal of Neurophysiology·Thomas HeinbockelMatthew Ennis
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel W WessonDonald A Wilson
Dec 4, 2012·Journal of Clinical and Diagnostic Research : JCDR·Biju Bahuleyan, Satendra Singh
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine L Kyuyoung, John R Huguenard
Mar 29, 2008·Neuropharmacology·Richard L YoungL Ashley Blackshaw
Jul 28, 2005·The European Journal of Neuroscience·Robert M DuvoisinJacob Raber

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