PMID: 5668537Aug 9, 1968

Metachromatic leukodystrophy: diagnosis with samples of venous blood

A K Percy, R O Brady


Arylsulfatase A and B have been demonstrated in preparations of human leukocytes. The level of activity of arylsulfatase A is markedly decreased in the preparations from patients with metachromatic leukodystrophy. Acid phosphatase and arylsulfatase B activities were normal. The assay of arylsulfatase A in leukocyte preparations can be useful in the diagnosis of metachromatic leukodystrophy while obviating the difficulties of current methods.


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Proceedings of the National Academy of Sciences of the United States of America
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