Metachronous metastasis confined to isolated lymph node after curative treatment of colorectal cancer.

International Journal of Colorectal Disease
Jeonghee HanByung Soh Min

Abstract

The incidence of lymph node metastasis (LNM) in colorectal cancer is known to be 2-6%, but little data are available regarding metachronous metastasis confined to isolated LN. The aim of this study is to determine the distribution of isolated LNM and the risk factors for survival of isolated LNM in colorectal cancer. We retrospectively reviewed consecutive patients with colorectal adenocarcinoma between January 2008 and December 2015 at a tertiary referral center. A total of 5902 patients with biopsy-proven colorectal adenocarcinoma treated via surgery were included. Multivariate Cox proportional hazards analysis was used to identify prognostic factors for overall survival. Of the 5902 patients, recurrent cases were 1326. Among the relapsed patients, 301 patients had isolated LNM (22.69%). Para-aortic (48.8%), pelvic (29.9%), and Lung hilum (10.0%) were the most common sites of isolated LNM; there were statistically significant differences in the distribution of isolated LNM between the colon and rectal cancer (p = 0.02). Approximately 80% of isolated LNM were diagnosed within 3 years. Multidisciplinary therapy for LNM, diagnosis time to LNM, the T-stage, and histological type of primary cancer were identified as independent pr...Continue Reading

References

Dec 1, 1984·Annals of Surgery·C G WillettC E Welch
Nov 1, 1982·Journal of Surgical Oncology·C K ChungJ A Stryker
Jan 1, 1997·Diseases of the Colon and Rectum·D I Obrand, P H Gordon
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Jun 14, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ottavio RenaGiuliano Maggi
Jul 29, 2003·Cell and Tissue Research·Michael S PepperMihaela Skobe
Oct 8, 2003·BMC Cancer·Alvaro FigueredoUNKNOWN Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
Apr 7, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard L GundersonRichard M Goldberg
Aug 7, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S SadahiroY Ohizumi
Mar 26, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F GuyotA M Bouvier
Jul 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hanna Kelly, Richard M Goldberg
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M JefferyP N Hider
Sep 6, 2007·Cancer Metastasis Reviews·Emmanouil FokasHan-Xiang An
Oct 30, 2007·Journal of Surgical Oncology·Byung Soh MinSeung Hyuk Baik
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott KopetzRobert R McWilliams
Sep 19, 2009·World Journal of Gastroenterology : WJG·Mi-Jung LeeKi Whang Kim
Nov 17, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T HamanoY Kobayashi
May 30, 2013·Surgical Neurology International·Rohan Ramakrishna, Robert Rostomily
May 21, 2014·Cancer Epidemiology·Yvette R B M van GestelValery E P P Lemmens
Jul 23, 2016·Journal of Cancer Research and Clinical Oncology·Ji Soo ParkHyun Cheol Chung

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Citations

May 28, 2021·Asian Journal of Surgery·Ke-Kang Sun, Yong-You Wu

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