Metachronous Spontaneous Remission of Melanoma Lung Metastasis and Mediastinal Lymph Node Metastases

Oncology Research and Treatment
Herbert Kappauf, Gregor Esser

Abstract

Spontaneous remissions are rare but valid events in malignancies and in the past have led to the development of mainstay oncologic therapies. We present a rare case of spontaneous regression of a solitary pulmonary melanoma metastasis with complete remission persisting for 28 months. Concurrent mediastinal nodal metastases progressed at the time of remission of the lung metastasis, but also demonstrated regression in follow-up fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging. Metastatic nodes showed only minimal residual metabolic activity after 38 months of follow-up from the appearance of metastatic disease. This case report presents a rare spontaneous complete regression of a solitary pulmonary melanoma metastasis. Biological pathways involved in spontaneous regression in cancer are discussed.

Citations

Sep 21, 2018·Apoptosis : an International Journal on Programmed Cell Death·Peng WangShuai He
Jul 10, 2021·Translational Oncology·Gudapureddy Radha, Manu Lopus

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