PMID: 9537864Apr 16, 1998Paper

Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial. Spanish Group for the Study of Alcoholic Fatty Liver

Journal of Hepatology
J CaballeríaJ Rodés

Abstract

Our aim was to investigate the effectiveness of metadoxine (pyridoxol L, 2 pyrrolidone-5-carboxylate) in the treatment of alcoholic fatty liver. A double-blind randomized multicenter trial involving 136 chronic active alcoholic patients diagnosed with fatty liver by clinical, biochemical and ultrasonographic criteria was performed. Patients were treated with 1500 mg/day of metadoxine (n = 69) or placebo (n = 67) for 3 months. Patients were clinically and biochemically evaluated every month. Ultrasonography was performed before and after treatment. At the end of the study there was a significant improvement in the liver function tests in both groups. However, the changes were more rapid and greater in patients treated with metadoxine, in whom significant changes in serum levels of bilirubin, aminotransferases and gammaglutamyl transpeptidase were already observed after 1 month of treatment, and normalization of these parameters was observed at the end. After treatment, the percentage of patients with ultrasonographic signs of steatosis was significantly lower in the metadoxine group (28% vs 70%, p < 0.01) and the degree of steatosis was also lower in this group. Sixteen patients treated with metadoxine and 15 with placebo contin...Continue Reading

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References

Jan 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G AnnoniB Arosio
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KamimuraH Tsukamoto
Feb 1, 1990·Seminars in Liver Disease·S L Friedman
Feb 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MatsuokaH Tsukamoto
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KawaseC S Lieber
Aug 1, 1986·Seminars in Liver Disease·R N MacSween, A D Burt
Jan 4, 1986·British Medical Journal·S H SaverymuttuJ D Maxwell
Jan 1, 1988·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·J CaballeríaJ Rodés
Feb 1, 1984·Journal of Clinical Ultrasound : JCU·E Lewis
Apr 1, 1994·Gastroenterology·C S Lieber
Sep 1, 1993·Baillière's Clinical Gastroenterology·M J RamondJ P Benhamou
May 1, 1993·Seminars in Liver Disease·E Mezey
Jun 1, 1993·Journal of Clinical Ultrasound : JCU·A Martínez-NogueraM Teixidó
Feb 1, 1996·Journal of Hepatology·P LetteronD Pessayre
May 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S RojterJ M Vierling
Oct 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christopher Paul Day

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Citations

Jul 28, 2010·Archives of Pharmacal Research·Dae Young LeeMyung Gull Lee
Mar 5, 2013·CNS Drugs·Giovanni AddoloratoRaffaele Landolfi
Mar 30, 2002·Alcoholism, Clinical and Experimental Research·Leonid S ShpilenyaGiovanni Addolorato
Dec 21, 2006·Substance Abuse Treatment, Prevention, and Policy·Irene GuerriniMario Guazzelli
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Kotacherry T ShenoyAngelo A Bignamini
Mar 8, 2014·World Journal of Gastroenterology : WJG·Ludovico AbenavoliGiovanni Addolorato
Sep 30, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Francislaine Ar Lívero, Alexandra Acco
Aug 28, 2003·Alimentary Pharmacology & Therapeutics·F StickelH K Seitz
Aug 5, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Pablo Muriel, Rogelio Deheza
Nov 20, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M C Gutiérrez-RuizD Kershenobich
Jul 28, 2004·Diabetes Care·Jesús MedinaRicardo Moreno-Otero
Dec 3, 2008·European Journal of Internal Medicine·Luisa VonghiaUNKNOWN Alcoholism Treatment Study Group
Jun 12, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Yi-Lang TangLorenzo Leggio
Feb 22, 2017·Alimentary Pharmacology & Therapeutics·E T Goh, M Y Morgan
Jan 8, 2004·The Journal of International Medical Research·J Fehér, G Lengyel
Mar 30, 2002·The Journal of International Medical Research·M C L R Díaz MartínezC Cruz Fuentes
Jan 18, 2017·Journal of Psychopharmacology·Carolina L Haass-KofflerLorenzo Leggio
Jan 23, 2015·The Cochrane Database of Systematic Reviews·Chavdar S PavlovChristian Gluud
Apr 4, 2017·The Cochrane Database of Systematic Reviews·Elena BuzzettiKurinchi Selvan Gurusamy
Jul 17, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Cynthia L VuittonetGeorge A Kenna
Oct 18, 2013·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Jun 27, 2001·Journal of Atherosclerosis and Thrombosis·Y OsonoY Hata
Mar 3, 2020·Frontiers in Pharmacology·Laxman SinghAtanas G Atanasov
Nov 13, 2003·International Journal of Immunopathology and Pharmacology·G AddoloratoG Gasbarrini
Oct 3, 2018·Journal of Clinical and Translational Hepatology·James J ConnollyJoseph K Lim
Nov 13, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Giovanni AddoloratoAntonio Gasbarrini
Nov 1, 2017·World Journal of Gastroenterology : WJG·Sukhpreet SinghKusum K Kharbanda
Feb 1, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giovanni AddoloratoElisa Stasi
Mar 7, 2021·Antioxidants·Mariapia VairettiClarissa Berardo

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