Metagenomic study focusing on antibiotic resistance genes from the sediments of River Yamuna

Gene
Basanta Kumar DasAnil Rai

Abstract

Antibiotic resistance is one of the major health concerns of the present century. The direct discharge of urban sewage, hospital effluents, and pharmaceutical wastes increases the concentration of antibiotics in riverine ecosystems. This provides selection pressure for the development of novel antibiotic-resistant strains. In this study, metagenomics approach was employed a for constructing a comprehensive profile of the Antibiotic Resistance Genes (ARGs) identified in the sediments of the Yamuna River. A total of 139 ARGs were identified from 39 microbial species. Abundance analysis revealed that, aminoglycoside, beta-lactam, macrolide, and tetracycline resistance genes were highly abundant in the sediment samples obtained from the Yamuna River. The evolutionary relationships among the ARGs were studied by phylogenetic analyses, which revealed that, the identified resistome comprised eight clusters. Network analysis was performed for investigating the broad-spectrum profiles of the ARGs and their enrichment in different biological functions and pathways. Protein-protein interaction (PPI) analyses revealed that, 76, 36, 18, and 5 Gene Ontology (GO)-terms were significantly enriched in Biological process, Molecular Function, Cel...Continue Reading

Citations

Mar 26, 2021·Environmental Science and Pollution Research International·Sakina BombaywalaSunil Kumar
Jul 5, 2021·Environmental Science and Pollution Research International·Majed AlsubihFazlollah Changani
Oct 15, 2021·Environmental Science and Pollution Research International·Vinay RajputMahesh S Dharne

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