Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions

Scientific Reports
Feng ZhangHang Gong

Abstract

This study described an efficient and practical approach for amide synthesis. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40 °C) in air, and readily available formamides were used as an amino source. This reaction can be easily upgraded to the gram level with an excellent yield.

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Citations

Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto SoleValentina Beghetto
Jul 31, 2021·Organic Letters·Jarvis Hill, David Crich

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Methods Mentioned

BETA
infrared spectroscopy

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